Synthesis and characterization of biocompatible Fe₃O₄ nanoparticles

Abstract

In this study, magnetite (Fe3O4) nanoparticles with a size range of 8-20 nm were prepared by the modified controlled chemical coprecipitation method from the solution of ferrous/ferric mixed salt-solution in alkaline medium. In the process, two kinds of surfactant (sodium oleate and polyethylene glycol) were studied; then, sodium oleate was chosen as the apt surfactant to attain ultrafine, nearly spherical and well-dispersed (water-base) Fe3O4 nanoparticles, which had well magnetic properties. The size and size distribution of nanoparticles were determined by particle size analyzer. And the magnetite nanoparticles was characterized by X-ray powder diffraction (XRD) analysis, transmission electron microscopy (TEM), electron diffraction (ED) photography, Fourier transform infrared spectrometer (FT-IR), and vibrating-sample magnetometer (VSM). Also the effect of many parameters on the Fe3O4 nanoparticles was studied, such as reaction temperature, pH of the solution, stirring rate and concentration of sodium oleate. And the 5-dimethylthiazol-2-yl-2,5- diphenyltetrazolium bromide (MTT) assay was performed to evaluate the biocompatibility of magnetite nanoparticles. The results showed that the Fe3O4 nanoparticles coated by sodium oleate had a better biocompatibility, better magnetic properties, easier washing, lower cost, and better dispersion than the magnetite nanoparticles coated by PEG.

Long‐Term Stability and Reproducibility of Magnetic Colloids Are Key Issues for Steady Values of Specific Power Absorption over Time

“…[22] [23] [24] Also, reverse micelle synthesis has been reported to give average particle sizes within 2.92 < <d> < 8.95 nm (i.e., 0.061< σ/<d> <0.12) [25] Besides Gen et al prepared α-FeOOH nanorods at room temperature by a micoremulsion approach whose size were 8.2 ± 1.5 nm (σ/<d>=0.18) in diameter and 106 ± 16 nm (σ/<d>=6.62)in length. [26] On the other hand, the reproducibility of both the average particle size and size distributions, as observed in figure 1, are excellent for the PEI-MNPs samples.…”

Preparation of Biocompatible Palladium-Fe3O4 Nanoparticles/Multiwalled Carbon Nanotubes Composite and its Electrocatalytic Activity towards Determination of Cholesterol on Screen Printed Electrode

“…PDDA is a water soluble, quaternary ammonium cationic polyelectrolyte. It is positively charged colloid when dissolved in aqueous solutions [31,32]. The positively charged PDDA polymer can be easily wrapped/coated on negatively charged MWCNTs [33].…”

Evaluation of Differences between Fe3O4 Micro- and Nanoparticles Properties

“…Size factor of powder particles affects their adsorption characteristics, which are determined by the surface energy level. Materials science approaches to the formation of the desired shape and character of the distribution as to the powder fractions will improve their functional properties [3,4].…”