Synthesis and characterization of biocompatible bimetallic-semi-aromatic polyester hybrid nanocomposite

Kumar, Rohit; Gupta, Piyush Kumar; Pandit, Soumya; Jha, Niraj Kumar; Ruokolainen, Janne; Kesari, Kavindra Kumar; Patil, Pravin P.; Narayanan, Shankar

doi:10.1016/j.colsurfa.2021.127845

Cited by 8 publications

(19 citation statements)

References 13 publications

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“… 18 No chemical interactions were seen between the copolymer and the produced hybrid nanocomposite; it was found to be crystalline and thermostable. 18 MnFe 2 O 4 @poly( t BGE-alt-PA) hybrid nanocomposite has a net negative charge on their outermost layer. Further, the nanocomposite was hemocompatible and biocompatible.…”

Section: Resultsmentioning

confidence: 98%

“…MnFe 2 O 4 @poly( t BGE-alt-PA) nanocomposite was synthesized and reported in our previous study. 18 In addition to the synthesis, we also characterized the physicochemical properties of the MnFe 2 O 4 @poly( t BGE-alt-PA) hybrid nanocomposite in our earlier paper. 18 FTIR spectroscopy demonstrated successful hybrid nanocomposite synthesis.…”

Section: Methodsmentioning

confidence: 99%

“… 18 In addition to the synthesis, we also characterized the physicochemical properties of the MnFe 2 O 4 @poly( t BGE-alt-PA) hybrid nanocomposite in our earlier paper. 18 FTIR spectroscopy demonstrated successful hybrid nanocomposite synthesis. X-ray diffraction technology characterized the crystal structure of the hybrid nanocomposite.…”

Section: Methodsmentioning

confidence: 99%

“… 18 The surface topology of the hybrid nanocomposite was studied through field emission scanning electron microscopy. 18 Using an MTT assay with mouse fibroblast cells (NIH3T3), the biocompatibility of the MnFe 2 O 4 @poly( t BGE-alt-PA) hybrid nanocomposite was evaluated. 18 The hemocompatiblity of the MnFe2O4@poly( t BGE-alt-PA) hybrid nanocomposite was studied by the in vitro hemolysis test.…”

Section: Methodsmentioning

confidence: 99%

“…We later found that the nanocomposite was both biocompatible and hemocompatible in nature. 18 In this work, we have evaluated the genotoxic and cytotoxic analysis of the newly developed metallo-polyester nanocomposites made up of MnFe 2 O 4 nanoparticles and poly(tBGE-alt-PA) copolymers on the model organism D. melanogaster . For more than a century, scientists have used the fruit fly D. melanogaster as a laboratory organism to investigate a wide range of aspects of biology, such as heredity effects, aging, learning, behavior, and embryonic development.…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Kumar

Bauri

Sahu

et al. 2023

ACS Appl. Bio Mater.

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Nanocomposites have significantly contributed to biomedical science due to less aggregation behavior and enhanced physicochemical properties. This study synthesized a MnFe2O4@poly(tBGE-alt-PA) nanocomposite for the first time and physicochemically characterized it. The obtained hybrid nanomaterial was tested in vivo for its toxicological properties before use in drug delivery, tissue engineering fields, and environmental applications. The composite was biocompatible with mouse fibroblast cells and hemocompatible with 2% RBC suspension. This nanocomposite was tested on Drosophila melanogaster due to its small size, well-sequenced genome, and low cost of testing. The larvae’s crawling speed and direction were measured after feeding. No abnormal path and altered crawling pattern indicated the nonappearance of abnormal neurological disorder in the larva. The gut organ toxicity was further analyzed using DAPI and DCFH-DA dye to examine the structural anomalies. No apoptosis and necrosis were observed in the gut of the fruit fly. Next, adult flies were examined for phenotypic anomalies after their pupal phases emerged. No defects in the phenotypes, including the eye, wings, abdomen, and bristles, were found in our study. Based on these observations, the MnFe2O4@poly(tBGE-alt-PA) composite may be used for various biomedical and environmental applications.

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Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Kumar

Bauri

Sahu

et al. 2023

ACS Appl. Bio Mater.

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Metal-polymer nanocomposites based on metal-containing monomers

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Uflyand²,

Zhinzhilo³

2022

Russ Chem Bull

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Emerging Trends in Zinc Ferrite Nanoparticles for Biomedical and Environmental Applications

Garg,

Chiu,

Krishnan

et al. 2023

Appl Biochem Biotechnol

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Synthesis and characterization of biocompatible bimetallic-semi-aromatic polyester hybrid nanocomposite

Cited by 8 publications

References 13 publications

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Metal-polymer nanocomposites based on metal-containing monomers

Emerging Trends in Zinc Ferrite Nanoparticles for Biomedical and Environmental Applications

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Synthesis and characterization of biocompatible bimetallic-semi-aromatic polyester hybrid nanocomposite

Cited by 8 publications

References 13 publications

In Vivo Toxicological Analysis of MnFe2O4@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of MnFe2O4@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

Metal-polymer nanocomposites based on metal-containing monomers

Emerging Trends in Zinc Ferrite Nanoparticles for Biomedical and Environmental Applications

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Product

Resources

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In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use

In Vivo Toxicological Analysis of MnFe₂O₄@poly(tBGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use