Synthesis and characterization of aminolevulinic acid gold nanoparticles: Photo and sonosensitizer agent for atherosclerosis

Gonçalves, Karina de Oliveira; Vieira, Daniel Perez; Courrol, Lilia Coronato

doi:10.1016/j.jlumin.2018.01.057

Cited by 29 publications

(14 citation statements)

References 35 publications

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“…Various modifications of the Au NPs have further enhanced their therapeutic effects. For example, Au NPs functionalized with δ‐aminolevulinic acid (ALA) or PPIX both showed a high efficiency for singlet oxygen generation under US irradiation, and increased the SDT effect through plasmon resonance and cavitation . Apart from Au NPs, Ag NPs and Pd‐based NPs have also shown sono‐activated effects.…”

Section: Inorganic Sonosensitizersmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Section: Inorganic Sonosensitizersmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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“…Das et al [52] prepared AuNPs by means of an environmentally friendly process using a biodegradable copolymer synthesized by the graft polymerization of hydroxyl ethyl starch (HES) and methylacrylate (MA). • which corresponds to the planes of (111), (200), (220), and (311), respectively, for AuNPs synthesized using chitosan oligosaccharide (COS) loaded with Paclitaxel (PTX) used as anticancer drug [43]. Parveen and Tremiliosi-Filho [33] reported the environmentally friendly synthesis of AuNPs using crude glycerol (CG) extracted from a plant that produces biodiesel.…”

Section: X-ray Spectroscopy: X-ray Diffraction Xrdmentioning

confidence: 99%

“…These authors found diffraction peaks at 2θ = 38. (111), (200), (220), (311), and (320) planes, indicating an fcc structure of Au, respectively. The authors compared the size of AuNPs prepared with the CG extracted from the biodiesel plant and commercial CG using the Scherrer equation, where the size of both AuNPs was 13 ± 3 nm.…”

Section: X-ray Spectroscopy: X-ray Diffraction Xrdmentioning

confidence: 99%

“…The authors found that the sizes of AuNFs depended on the PPDDs concentration, i.e., at a medium concentration of PPDDs, spherical NPs were formed. From the XRD results, AuNFs XRD patterns showed peaks of (111), (200), (220), (311), and (222), which was characteristic of fcc and polycrystalline structures. Moreover, the intensity ratio between the peaks (111)/(200) was 2.21, which is larger than that of spherical AuNPs (1.9), the latter attributed to a preferential growth of AuNFs 111 [107] reported the formation of hybrid composites containing polyaniline and AuNPs by using sodium citrate (CITRATE) as reducing agent and polyaniline emeraldine-salt form (ES-PANI) as stabilizer.…”

Section: X-ray Spectroscopy: X-ray Diffraction Xrdmentioning

confidence: 99%

“…In addition, the results obtained during in-vivo tests suggested that NPs exhibited great potential in the detection of atherosclerotic lesions [219]. AuNPs functionalized with PEG have also been employed in the photodynamic and sonodynamic therapies of atherosclerosis [220]. Diseases such as Mycobacterium tuberculosis, obesity, and liver heart disease have also been targeted by nanomedicine for treatment and diagnosis.…”

Section: Treatment Of Other Diseasesmentioning

confidence: 99%

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Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

et al. 2019

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The fundamental aspects of the manufacturing of gold nanoparticles (AuNPs) are discussed in this review. In particular, attention is devoted to the development of a simple and versatile method for the preparation of these nanoparticles. Eco-friendly synthetic routes, such as wet chemistry and biosynthesis with the aid of polymers, are of particular interest. Polymers can act as reducing and/or capping agents, or as soft templates leading to hybrid nanomaterials. This methodology allows control of the synthesis and stability of nanomaterials with novel properties. Thus, this review focus on a fundamental study of AuNPs properties and different techniques to characterize them, e.g., Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), UV-Visible spectroscopy, Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy, Small-angle X-Ray Scattering (SAXS), and rheology. Recently, AuNPs obtained by “green” synthesis have been applied in catalysis, in medicine, and as antibacterials, sensors, among others.

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Transition Metal‐Based Therapies for Inflammatory Diseases

2023

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Inflammatory disease (ID) is a general term that covers all diseases in which chronic inflammation performs as the major manifestation of pathogenesis. Traditional therapies based on the anti‐inflammatory and immunosuppressive drugs are palliative with the short‐term remission. The emergence of nanodrugs has been reported to solve the potential causes and prevent recurrences, thus holding great potential for the treatment of IDs. Among various nanomaterial systems, transition metal‐based smart nanosystems (TMSNs) with unique electronic structures possess therapeutic advantages owing to their large surface area to volume ratio, high photothermal conversion efficiency, X‐ray absorption capacity, and multiple catalytic enzyme activities. In this review, the rationale, design principle, and therapeutic mechanisms of TMSNs for treatments of various IDs are summarized. Specifically, TMSNs can not only be designed to scavenge danger signals, such as reactive oxygen and nitrogen species and cell‐free DNA, but also can be engineered to block the mechanism of initiating inflammatory responses. In addition, TMSNs can be further applied as nanocarriers to deliver anti‐inflammatory drugs. Finally, the opportunities and challenges of TMSNs are discussed, and the future directions of TMSN‐based ID treatment for clinical applications are emphasized.

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Synthesis and characterization of aminolevulinic acid gold nanoparticles: Photo and sonosensitizer agent for atherosclerosis

Cited by 29 publications

References 35 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

Transition Metal‐Based Therapies for Inflammatory Diseases

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