Synthesis and characterization of acrylic acid-containing dextran hydrogels

Chiu, Hsin‐Cheng; Wu, Anjun; Lin, Yu-Hao

doi:10.1016/s0032-3861(00)00523-1

Cited by 57 publications

(35 citation statements)

References 38 publications

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“…This sort of pH-sensitive hydrogels were presented in the literature. 5 We have observed that only a very small quantity of drug was released in the acidic pH. The hydrolysis rate of crosslinker employed in the formation of hydrogels was increased noticeably in the alka- line pH (as should be expected) because of the nature of the labile ester bond that can be hydrolyzed in the presence of a base catalyst.…”

Section: Effect Of Ph On the Releasing Rate Of The Drugmentioning

confidence: 62%

In vitro drug release studies of 2‐hydroxyethyl acrylate or 2‐hydroxypropyl methacrylate‐4‐{(1E,4E)‐5‐[4‐(acryloyloxy)phenyl]‐3‐oxopenta‐1,4‐dienyl}phenyl acrylate copolymer beads

Arun

Reddy

2005

J Biomed Mater Res

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4-{(1E,4E)-5-[4-(Acryloyloxy)phenyl]-3-oxopenta-1,4-dienyl}phenyl acrylate (APPA) was synthesized by reacting (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one (HPD) and acryloyl chloride using triethylamine as a base. 2',4-Dichloro-5'-fluoro-1-ene-2-(4-hydroxyphenyl)phenone (EHP) (Arun A, Reddy BSR, Rajkumar M. Polymeric drug for antimicrobial activity studies: Synthesis and characterization. J Bioact Compat Polym 2003;18:219) was used for the controlled release studies. Two types of porous hydrogels were prepared by copolymerizing 2-hydroxyethyl acrylate (HEA) or 2-hydroxypropyl methacrylate (HPMA) with APPA (as a crosslinker) by employing the suspension polymerization technique. The morphology of the hydrogels were characterized by the optical microscopy (OM) and scanning electron microscopy (SEM). Different variations were employed in the preparation of hydrogels to study the effect of crosslinker percentage and drug the loading percentage. Totally 18 types of hydrogels were prepared. The drug-releasing pattern was monitored over a period of 4 weeks using the UV spectroscopic technique by measuring the absorptions at 330.5 nm. In vitro release experiments were carried out at pH 7.4 and pH 9.2. In total, 36 releasing experiments were conducted. The results showed that the controlled release of the drug was dependent on the monomer (HEA or HPMA), crosslinker percentage (CLP), drug-loading percentage (DLP), and pH. The release rate was higher for HEA-based hydrogels when compared with HPMA-based hydrogels in all compositions. The release rate was noticeably higher in pH 9.2 than pH 7.4.

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Section: Effect Of Ph On the Releasing Rate Of The Drugmentioning

confidence: 62%

In vitro drug release studies of 2‐hydroxyethyl acrylate or 2‐hydroxypropyl methacrylate‐4‐{(1E,4E)‐5‐[4‐(acryloyloxy)phenyl]‐3‐oxopenta‐1,4‐dienyl}phenyl acrylate copolymer beads

Arun

Reddy

2005

J Biomed Mater Res

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“…As well described by several authors, the degradability of dextran derivatives by dextranase is significantly affected by the type and the extent of chemical modification [26,27] and the degree of substitution DS of dextran molecules [28]. Furthermore, the dextran esters slightly substituted (DS=1) by small chain of fatty acids, i.e.…”

Section: Enzymatic Degradation Of Different Dextran Estersmentioning

confidence: 92%

Synthesis and characterization of dextran esters as coating or matrix systems for oral delivery of drugs targeted to the colon.

Beesh¹,

Majewska²,

Th.³

2010

Int. J. Drug Delivery

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Abstract:Different dextran esters with various degrees of substitution (1, 2 and 3) were synthesized by esterification reaction, with three acid anhydrides: acetic anhydride, propionic anhydride, and butyric anhydride, separately. These modified polysaccharides were characterized by FT-IR, 1 H NMR and 13 C NMR spectroscopies. Enzymatic degradation of biopolymers by dextranase was also studied. The polymers showing the best degradation profiles were chosen to design blended free films in combination with a polymethacrylate (Eudragit® RS 30D) as a sustained release system for targeting to the colon. These free films were evaluated by permeability of theophylline used as tracer in different in vitro media of the gastro intestinal tract, in presence or in absence of dextranase. From these studies, it was concluded that dextran esters having the lower degree of substitution and constituted of short carbohydrate chains showed the best and significant enzymatic degradation and could be used as a promising carrier for specific colon drug delivery system.

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“…They are utilized in drug delivery 3,4 system because of their unique capability of swelling under biological conditions alongwith immobilization of proteins, peptides and other therapeutically active compounds 5 . Properties of the swelling medium like pH 6 , ionic strength 7 and counter ions 8 primarily affects the swelling characteristic of the hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Synthesis Of Gum Tragacanth-Cl-Poly (Acrylic Acid) Superabsorbent Hydrogels with Salt, pH and Electrical Responsive Properties

Prashar¹

2017

PBJ

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The Gum tragacanth-acrylic acid-based hydrogels were prepared using KPS-ascorbic acid as an initiator and glutaraldehyde as crosslinker via free radical graft copolymerization technique. Synthesized polymers were characterized with FTIR, SEM and thermal techniques in order to authenticate the grafting of poly (AA) on to Gum tragacanth. The candidate's hydrogel was also evaluated for salt resistant distension studies by means of biological electrolytic system using AC/DC supply. Moreover, the re-swelling ability of the candidate polymer was also studied using different pH media for its utilization in the site specific drug delivery. The results of the study suggested that the candidate polymer shows good salt resistant behavior alongwith pulsatile (swelling/de-swelling) nature. From the results of present study it was concluded that the polymer can be utilized for targeted drug delivery system as carrier.

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Synthesis and characterization of acrylic acid-containing dextran hydrogels

Cited by 57 publications

References 38 publications

In vitro drug release studies of 2‐hydroxyethyl acrylate or 2‐hydroxypropyl methacrylate‐4‐{(1E,4E)‐5‐[4‐(acryloyloxy)phenyl]‐3‐oxopenta‐1,4‐dienyl}phenyl acrylate copolymer beads

In vitro drug release studies of 2‐hydroxyethyl acrylate or 2‐hydroxypropyl methacrylate‐4‐{(1E,4E)‐5‐[4‐(acryloyloxy)phenyl]‐3‐oxopenta‐1,4‐dienyl}phenyl acrylate copolymer beads

Synthesis and characterization of dextran esters as coating or matrix systems for oral delivery of drugs targeted to the colon.

Synthesis Of Gum Tragacanth-Cl-Poly (Acrylic Acid) Superabsorbent Hydrogels with Salt, pH and Electrical Responsive Properties

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