Synthesis and characterization of a new azo quinoline ligand and its metal complexes with spectrophotometric determination and biological efficacy study of its Hg(II) complex

Abstract

ABSTRACT. An azo quinoline ligand, (E)-2-((4-iodophenyl)diazenyl)-8-hydroxyquinoline (IPDHQ), was synthesized by the coupling reaction of 4-iodoaniline diazonium salt with 8-hydroxyquinoline. The synthesized ligand and its Cd(II), Pd(II), Cu(II) and Hg(II) complexes were spectrally characterized by UV‒Vis spectrophotometry, FT-IR, mass spectral analysis, 1H-NMR, magnetic sensitivity and molar conductivity. The general formula of the Cd(II), Cu(II) and Hg(II) complexes is [M(L)2].Cl2.H2O with octahedral geometry, while the general formula of the Pd(II) complex is [M(L).Cl2].H2O with square planer geometry. A simple and rapid spectrophotometric procedure was suggested for the determination of Hg(II) using the synthesized ligand as a spectrophotometric reagent. By measuring the absorbance for the resulting orange complex at 430 nm, the linearity range was 0.5-15 µg mL-1, and the interfering effect was also studied. The synthesized azo ligand and its Hg(Ⅱ) complex were tested for their biological activity against four bacterial strains.
 KEY WORDS: Azo quinoline ligand, 8-Hydroxy quinoline, 4-Iodoaniline, Azo metal complexes, Spectrophotometric determination, Biological efficacy study
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1459-1470. DOI: https://dx.doi.org/10.4314/bcse.v37i6.13

Synthesis, characterisation, and anticancer and antioxidant activities of novel complexes of palladium and an organic Schiff-base ligand

“…Biological features play a major role in the significance of the Schiff-base complexes involving Pd(II) ions [7]. Recent studies [8] have been conducted on the coordination chemistry and biological effects of mixed ligand complexes of Pd(II), Zn(II), and Cd(II); research also exists on the coordination chemistry and thermal analysis of Hg(II) with a mixed ligand comprising a Schiff-base anion, phosphine, pyridine, and bipyridine as co-ligands [4,[9][10][11]. These ligands are adaptable and exist in both neutral and anionic forms.…”