2013
DOI: 10.1590/s1984-82502013000200010
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Synthesis and characterization of a cysteine xyloglucan conjugate as mucoadhesive polymer

Abstract: The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugates were prepared at varying reaction pH (2-6) and evaluated for optimum thiol incorporation, disulphide group content, swelling behavior, rheological properties and mucoadhesive properties. The obtained conjugat… Show more

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Cited by 16 publications
(7 citation statements)
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References 21 publications
(11 reference statements)
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“…Therefore, once polymerization completed, spectrum for C=C at 1637cm -1 (Figure 1(a)) will disappear as shown in the ATR spectra (Figure 1(c)). Besides, the second possible reaction is condensation process between hydroxyl group of the HEMA with carboxylic acid of the cystine forming ester bond which it is in agreement with the previous study reported (Bhalekar et al 2013). In addition, the elements for breaking and reformation of disulphide bond on the hydrogel for thermally healing system will be explored in the future.…”
Section: Resultssupporting
confidence: 91%
“…Therefore, once polymerization completed, spectrum for C=C at 1637cm -1 (Figure 1(a)) will disappear as shown in the ATR spectra (Figure 1(c)). Besides, the second possible reaction is condensation process between hydroxyl group of the HEMA with carboxylic acid of the cystine forming ester bond which it is in agreement with the previous study reported (Bhalekar et al 2013). In addition, the elements for breaking and reformation of disulphide bond on the hydrogel for thermally healing system will be explored in the future.…”
Section: Resultssupporting
confidence: 91%
“…l-Cystine acted as a cross-linker by the condensation reaction of its carboxyl groups with the hydroxyl groups of the HEMA, forming ester bonds, which is in agreement with the result of a previous study (11). However, future work needs to be done for further confirmation of the ester bond from the cross-linking reaction and for comparison between poly(HEMA) with and poly(HEMA) without a cross-linker.…”
Section: Resultssupporting
confidence: 89%
“…Agarose gels were prepared with an existing method (Gao et al ), but suspensions of sorbents in agarose were based on custom formulations. Sulfur‐functionalized polymers were identified in the biomedical (Bernkop‐Schnürch et al ; Duan and Lewis ; Bhalekar et al ) or water treatment (Yu et al ) literature. A method for embedding AC in a polyvinylidene fluoride (PVDF) polymer was adapted from an electrochemistry application (Choi ).…”
Section: Methodsmentioning
confidence: 99%
“…References or sources for polymers and sorbents: ag, Gao et al (); Cys+alg, Bernkop‐Schnürch et al (); Cys+xylo, Bhalekar et al (); ag+MAA‐chit, Kast and Bernkop‐Schnürch (2001); ag+MPTMS‐DE, Yu et al (); SAMMS, Steward Environmental Solutions; agPEG, Charlionet et al (1996); CA, Membrane Filtration Products; MA, Aoki et al (2007); CN, Membrane Filtration Products; DE, Honeywell; MPTMS‐DE, Yu et al (); parafilm, Bemis; PDMS, Altec; PES, Goodfellow Cambridge; PET+Cys, Duan and Lewis (); POM38, CS Hyde; PTFE, Grainger.…”
Section: Methodsmentioning
confidence: 99%