Synthesis and Characterization of a Novel pH-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery

Veeramachineni, Anand Kumar; Sathasivam, Thenapakiam; Paramasivam, Ragul; Muniyandy, Saravanan; Pushpamalar, Janarthanan

doi:10.1007/s10924-019-01448-5

Cited by 15 publications

(7 citation statements)

References 39 publications

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“…The statistical significance of the release data of two hydrogels possessing similar viscosities, the neutral and negatively charged one, is illustrated in Figure 6 d. In this way, it was possible to assess the effect of different chemical structures/interactions in the compared hydrogels on IBU release properly, showing, in general, a higher IBU diffusion from anionic hydrogels in comparison with the neutral ones (probably due to the repulsive Coulomb forces between negatively charged groups in the ionic polymers and negatively charged (carboxylate) group of IBU). Similar to our interpretation of the effect of repulsive ionic interactions between the tested anionic hydrogels (NaCMC, CMC, TRG, CRG, XTG) and IBU on the drug diffusion, Veeramachineni et al [ 43 ] reported the effect of ionic repulsion between the anionic carboxymethyl TRG and anionic diclofenac sodium on drug entrapment efficiency.…”

Section: Resultssupporting

confidence: 89%

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Mikušová

Ferková

Dominika

et al. 2022

Gels

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Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. Due to their variable physical-chemical properties, polysaccharides have potentialities to be used for designing new drug delivery systems for controlled drug release. In this comparative study, rheological and texture properties as well as the in vitro release of model drug ibuprofen (IBU) with 11 polysaccharide-based hydrogels were investigated. The in vitro release of IBU significantly differed between (i) neutral (hydroxy/alkylcelluloses), (ii) anionic (carboxyalkylcellulose and its sodium salt, tragacanth, carrageenan, xanthan gum), and (iii) cationic (chitosans) hydrogels due to different contribution of provided interactions and viscosity within the hydrogel groups. The drug release kinetics of each hydrogel system was evaluated for five kinetic models. Several combinations of cationic hydrogels with neutral or anionic ones were performed to illustrate possibilities of providing modified IBU release profiles. In this context, chitosan was presented as an effective modifier of diffusion profiles for negatively charged drugs formulated into combined polymeric systems, providing their prolonged release. The most appropriate hydrogel for the topical application (i.e., providing favorable rheological and texture properties along with the highest drug release) was selected from a studied series of polysaccharide-based hydrogels.

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Section: Resultssupporting

confidence: 89%

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Mikušová

Ferková

Dominika

et al. 2022

Gels

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“…Veeramachineni et al [ 157 ] prepared carboxymethyl tragacanth-based microparticles with diclofenac sodium as a model drug. The analyzed system was manufactured by ionotropic gelation with aluminum chloride.…”

Section: Gum-based Micro- and Nanoparticles In Drug Deliverymentioning

confidence: 99%

Natural Gums in Drug-Loaded Micro- and Nanogels

et al. 2023

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Gums are polysaccharide compounds obtained from natural sources, such as plants, algae and bacteria. Because of their excellent biocompatibility and biodegradability, as well as their ability to swell and their sensitivity to degradation by the colon microbiome, they are regarded as interesting potential drug carriers. In order to obtain properties differing from the original compounds, blends with other polymers and chemical modifications are usually applied. Gums and gum-derived compounds can be applied in the form of macroscopic hydrogels or can be formulated into particulate systems that can deliver the drugs via different administration routes. In this review, we present and summarize the most recent studies regarding micro- and nanoparticles obtained with the use of gums extensively investigated in pharmaceutical technology, their derivatives and blends with other polymers. This review focuses on the most important aspects of micro- and nanoparticulate systems formulation and their application as drug carriers, as well as the challenges related to these formulations.

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“…Carboxymethylation of TG can lead to site‐directed drug release owing to its pH‐sensitive carboxylic functional groups. [ 33 ] There are two significant differences between CMT and other tragacanth derivatives. First, the hydrophilic carboxymethyl functional groups (CH 2 COO − ) have an effect on the absorption of water and hydrogen bonding which in fact, it indirectly adjusts the lipophilicity of the compound.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

2023

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In this research, a novel nanocarrier is synthesized based on tragacanth as a natural polysaccharide. For this purpose, carboxymethyl tragacanth (CMT) is first synthesized from tragacanth and then it is functionalized with isocyanate (IS) groups. In another parallel synthesis, magnetite nanoparticles (MNPs) are prepared by the co-precipitation method and coated with SiO 2 to form MNPs coated SiO 2 (MNPs@SiO 2 ). Then MNPs@SiO 2 is reacted with CMT-IS to form Fe 3 O 4 @SiO 2 /CMT. In the second step, the MNPs@SiO 2 /CMT surface is aminated by reaction with 3-amino propyl triethoxy silane (APTES) and then it is reacted with folic acid (FA) as a targeting agent to form MNPs@SiO 2 /CMT/FA nanocarrier. The synthesized nanocarrier is characterized by FT-IR, SEM, EDX, TEM, XRD, VSM, TGA, and zeta potential analysis and then it is loaded with doxorubicin (DOX) as a typical anti-cancer drug. The in vitro drug release studies are carried out from the DOX-loaded nanocarrier. The pH sensitivity of the DOX-loaded nanocarrier is examined attwo different pHs. The effect of DOX-loaded nanocarrier is investigated on MCF7 human breast cancer cells and the rate of cancer cell death is determined by MTT assay and drug IC50. The changes in the morphology of the tumor cell nuclei are observed using fluorescence microscopy.

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Synthesis and Characterization of a Novel pH-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery

Cited by 15 publications

References 39 publications

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Natural Gums in Drug-Loaded Micro- and Nanogels

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

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