Synthesis and characterization of a novel drug-loaded polymer, poly(lactic acid-co-aminomethyl benzimidazole)

Abstract

2015): Synthesis and characterization of a novel drug-loaded polymer, poly(lactic acid-co-aminomethyl benzimidazole), Designed Monomers and Polymers, Using aminomethyl benzimidazole (AMB) as a model of benzimidazole-type drugs, a potential biodegradable drug-loaded polymer poly(lactic acid-co-aminomethyl benzimidazole) (PLAAMB) is synthesized as designed via direct melt polycondensation starting from D,L-lactic acid (LA). When the molar feed ratio LA/AMB is 40/1, the optimal synthetic conditions, including catalyst type and dosage, polycondensation temperature, and copolymerization time are discussed. After the prepolymerization at 140°C for 8 h, using 0.4 wt% stannous oxide (SnO) as the catalyst, the melt copolymerization at 160°C for 6 h gives the copolymer with the biggest weight-average molecular weight (M w ) 5300 Da. The structure and properties of the copolymer are systematically characterized with Fourier transform infrared, 1 H NMR, gel permeation chromatography, differential scanning calorimetry, and X-ray diffraction. And the investigations on the influences of different molar feed ratios on the properties of PLAAMB show that, the copolymer PLAAMB with the biggest M w of 9400 Da can be obtained. After the drug model AMB as a monomer is introduced into polylactic acid during the condensation, the T g of the obtained PLAAMB is lower than the T g of homopolymer poly(D,L-lactic acid) (PDLLA). The M w and crystallinity of PLAAMBs can meet the requirement of drug-loaded polymers in the drug delivery.

Effect of Polymer Concentration, Rotational Speed, and Solvent Mixture on Fiber Formation Using Forcespinning®

“…The polymer/solvent miscibility has been shown to have a direct bearing on the final fiber diameter and morphology. For instance, fibers made from PLA in dichloromethane have been shown to have a broader range of fiber diameters [32][33][34]. Results reported by Wei et al [35] on the electrospinning of Polyvinylidene fluoride (PVdF) nanofibers showed that the concentrations of solvent Methyl ethyl ketone (MEK) in DMF greatly influenced the dimensions and morphology of PVdF nanofibers.…”

Single-Emulsion P(HB-HV) Microsphere Preparation Tuned by Copolymer Molar Mass and Additive Interaction

“…Biodegradable polymer microspheres have been extensively investigated as potential carriers for drugs, − cosmetic products, − delivery systems, and for diagnostic purposes because of their biocompatibility, biodegradability, stability, and sustained-release properties. , Among the most studied materials for encapsulation are derivatives of poly­( d , l -lactide), poly­( d , l -lactide- co -glycolide) (PLGA), and poly-ε-caprolactones, and the most widespread mechanism for encapsulation with them is the total enfold of the molecule of interest by the polymeric thin film to generate a spherical microparticle.…”