Synthesis and characterization of a porous poly(hydroxyethylmethacrylate‐co‐ethylene glycol dimethacrylate)‐based hydrogel device for the implantable delivery of insulin

Abstract

Poly(hydroxyethylmethacrylate-co-ethylene glycol dimethacrylate) [poly(HEMA-co-EGDMA)]-based hydrogel devices were synthesized by a free-radical polymerization reaction with 2-hydroxyethylmethacrylate as the monomer, different concentrations of ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent, and ammonium persulfate/N,N,N 0 ,N 0 -tetra-methyl ethylenediamine as the free-radical initiator. The porosity of the poly(HEMA-co-EGDMA) hydrogels was controlled with water as the porogen. The Fourier transform infrared spectrum of poly(HEMA-co-EGDMA) showed absorption bands associated with AC¼ ¼O stretching at 1714 cm À1 , CAOAC stretching vibrations at 1152 cm À1 , and a broad band at 3500-3800 cm À1 corresponding to AOH stretching. Atomic force microscopy studies showed that the hydrogel containing 67% water had pores in the range of 3500-9000 nm, whereas the hydrogel containing 7% water did not show measurable pores. The hydrogel synthe-sized with 1% EGDMA showed 50% thallium-201 release within the first 30 min and about 80% release within 60 min. In vitro insulin-release studies suggested that the hydrogel with 27% water showed sustained release up to 120 min, whereas the hydrogels with 47 and 67% water showed that nearly all of the insulin was released within 60 min. Hydrogel devices synthesized with 27% water and filled with insulin particles showed sustained release for up to 8 days, whereas the hydrogels synthesized with 47 and 67% water released insulin completely within 3 days of administration. Animal studies suggested that the hydrogel devices synthesized with 27% water and filled with insulin-loaded particles (120 IU) were able to control blood glucose levels for up to 5 days after implantation. V C 2012 Wiley Periodicals, Inc. J Appl Polym Sci 126: [894][895][896][897][898][899][900][901][902][903][904][905] 2012

Hydroxyethyl Methacrylate Based Nanocomposite Hydrogels With Tunable Pore Architecture

“…Hydroxyethyl methacrylate based hydrogels are highly hydrophilic and biocompatible. These characteristics have enabled their use in biomedical field for applications such as contact lenses, drug delivery [10][11][12], and tissue engineering [13][14][15][16]. Owing to their high surface area, HEMA based hydrogels have found application also in environmental remediation such as removal of dyes from industrial waste waters [17,18], and in separation [19].…”

Dual‐bonding structured ternary composite film of poly(vinyl alcohol)–boric acid–nanodiamond

“…As shown in Figure (C), the spectra of PVA and PVA/DND are identical, while those for BA‐bearing films are of a similar shape. For pure PVA and PVA/DND films, the peak centered at 1152 cm −1 was due to COC symmetric stretching vibration . When BA was introduced, the peak blue shifted to 1163 cm −1 and was strengthened, which testified there is a strong bonding in the form of BOC occurred between BA and DND or PVA, and the adsorption peak shifted as BOC stretching possesses higher vibration frequency.…”

Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

“…HEMA is, among others, a precursor for the production of contact lenses, soft tissues, and vascular prostheses and can be used as a drug carrier. 35 EGDMA, in turn, is used to prepare bioinspired composites with interesting properties, for instance photocurable dental materials, 36 systems directed towards reduced oxidative stress and co-stimulatory factor expression in human monocytic cells, 37 porous hydrogel devices for the implantable delivery of insulin, 38 etc. Both materials, as polymers and copolymers, possess various advantages such as biocompatibility, hydrophilicity, and hardness similar to that observed for human bones and can be used as the filling of bone or tooth defects.…”