Synthesis and characterization of a novel alginate–poly(ethylene glycol) graft copolymer

Laurienzo, Paola; Malinconico, Mario; Motta, Andréa; Vicinanza, A.

doi:10.1016/j.carbpol.2005.08.005

Cited by 118 publications

(66 citation statements)

References 14 publications

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“…The X-ray diffraction (XRD) analysis of the three PLGGE polymers is illustrated in Figure 1. The spectrum of PLGGE2000 showed two strongest diffraction peaks at 2θ =19.2° and 23.2° which were the typical crystal of mPEG [28]. The PLGGE2000 also presented relative lower diffraction peaks at 2θ =16.8°.…”

Section: Properties Of the Plgge Copolymersmentioning

confidence: 94%

“…This was caused by the side chain of mPEG2000. Table 1 showed a slight decrease of T m from 56°C (in mPEG2000) to 52.4°C in PLGGE2000 copolymer, the graft of mPEG disturbed the crystallization process [28,29]. With the increase of mPEG content, the H c value of the cold crystallization peak of PLGGE copolymers decreased.…”

Section: Properties Of the Plgge Copolymersmentioning

confidence: 94%

“…The tendency was similar. The first weight losses of three PLGGE copolymers starting from about 233°C were assigned to the decomposition of the polymer backbone (PLGG), while the subsequent weight losses at about 387°C were attributed to the decomposition of the grafted mPEG chains [28]. Furthermore, the PLGGE2000, PLGGE1100 and PLGGE500 lost 51.88%, 72.56% and 84.17% of their weights.…”

Section: Properties Of the Plgge Copolymersmentioning

confidence: 99%

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Novel PLGGE graft polymeric micelles for doxorubicin delivery

Sheng

et al. 2012

Chin. Sci. Bull.

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Novel poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-g-monomethyl poly(ethylene glycol) (PLGGE) micelles were prepared and used as carriers for anti-tumor drug delivery. Three PEGylated PLGG copolymers (PLGGE2000, PLGGE1100 and PLGGE500) were characterized by XRD, TG and DSC. The critical micelle concentrations (CMCs) of the amphiphilic copolymers were 1.04, 0.55 and 0.13 μg/mL, respectively. The TEM, AFM and DLS measurements revealed that the micelles were homogeneous spherical nanoparticles with the diameters ranged from 50 to 150 nm when THF was used as solvent in the preparation of the micelles. Interestingly, extended cylindrical micelles were obtained using CHCl 3 as solvent. The micelles could trap doxorubicin (DOX) in the core with the highest drug loading content up to 23.7%. The mean diameter of drug loaded micelles was much bigger than that of blank micelles. The in vitro drug release of the micelles was diffusion-controlled release within the first 36 h and initial burst release was not obvious. However, after 36 h, the release rate in pH 5.0 was faster than that in pH 7.4 due to the degradation. The PLGGE micelles were nontoxic to both NIH 3T3 fibroblasts and HepG2 cells. The in vitro cytotoxicity against HepG2 cells demonstrated that the drug loaded micelles exhibited high inhibition activity to cancer cells. CLSM observation of HepG2 cells showed that DOX released from the micelles could be delivered into cell cytoplasm and cell nuclei. PLGGE micelles are potential promising carriers for anti-tumor drug delivery. PLGGE, micelles, drug delivery, doxorubicin Citation:Yu Z X, He B, Sheng M M, et al. Novel PLGGE graft polymeric micelles for doxorubicin delivery.

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Section: Properties Of the Plgge Copolymersmentioning

confidence: 94%

Section: Properties Of the Plgge Copolymersmentioning

confidence: 94%

Section: Properties Of the Plgge Copolymersmentioning

confidence: 99%

See 1 more Smart Citation

Novel PLGGE graft polymeric micelles for doxorubicin delivery

Sheng

et al. 2012

Chin. Sci. Bull.

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“…It was introduced into several biomaterials and drugs because of good immunogenicity and the ability of preserving the biological properties of proteins. PEGylation of chitosan (Ganji & Abdekhodaie, 2008;Jeong, Kim, Jang, & Nah, 2008;Sugimoto, Morimoto, Sashiwa, Saimoto, & Shigemasa, 1998), poly(lactic acid) (Huh & Bae, 1999) and alginate (Laurienzo, Malinconico, Motta, & Vicinanza, 2005) to improve their solubility, gelation ability or stability have been reported. This study describes the synthesis and characterization of a carboxymethyl KGM grafted monomethoxy PEG (CKGM-g-mPEG) 0144-8617/$ -see front matter Ó copolymer with grafted PEG oligomers on the high molecular weight KGM.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Xia

Meng

et al. 2010

Carbohydrate Polymers

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“…Muchas y muy variadas son las técnicas [225,222,240], de obtención de microcápsulas, la elección se realiza dependiendo de las características de la materia activa que se desea encapsular y del tipo de material polimérico que se use como membrana.…”

Section: 2-obtención De Microcápsulasunclassified

Caracterización de microencapsulados aplicados sobre materiales textiles

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Synthesis and characterization of a novel alginate–poly(ethylene glycol) graft copolymer

Cited by 118 publications

References 14 publications

Novel PLGGE graft polymeric micelles for doxorubicin delivery

Novel PLGGE graft polymeric micelles for doxorubicin delivery

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Caracterización de microencapsulados aplicados sobre materiales textiles

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