Synthesis and characterization of a new magnetic restricted access molecularly imprinted polymer for biological sample preparation

Mendes, Tássia Venga; Franqui, Lidiane S.; Santos, Mariane Gonçalves; Wisniewski, Célio; Figueiredo, Eduardo Costa

doi:10.1016/j.mtcomm.2020.101002

Cited by 20 publications

(11 citation statements)

References 48 publications

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“…According to the TEM images ( Figure 5 A,B), after another modification in which the layer of polymer was immobilized on a magnetic particle, it had a more homogeneous distribution than basic Fe 3 O 4 and Fe 3 O 4 @SDS@OA [ 36 ]. Meanwhile, after the removal of the template molecule, MMIPs were characterized by a more visible porous structure with cavities [ 37 , 38 ]. Moreover, when comparing MMIP and MNIP, one can see that the former were smaller, exactly due to the fact that the template was washed out ( Figure 5 C,D).…”

Section: Resultsmentioning

confidence: 99%

“…As can be seen from the results collected in Table 3 , only one text was found, which described the use of a polymer with an imprinted particle with magnetic properties [ 26 ]. In most cases, sample preparation was based on the use of the obtained sorbent in the SPE [ 27 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], which requires packing an SPE cartridge. In our opinion, the use of the sorbent in bulk form as a dispersive solid-phase extraction allows a quicker sample preparation.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

et al. 2020

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Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r2 from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL−1; LOQ from 3.6–8.1 ng mL−1), which makes their quantitative analysis in real samples feasible.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

et al. 2020

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“…6,7 A large number of published analytical methods have been used as restricted access molecularly imprinted polymer (RAMIP), especially those coated with bovine serum albumin (RAMIP-BSA), as an adsorbent in online or offline analytical systems. [8][9][10] These materials are based on molecularly imprinted polymers (MIPs) which are synthetic polymers capable of recognizing specific molecules in terms of shape, size, and chemical functionality. Generally, MIPs operate by covalent and non-covalent interactions (van der Waals forces, ionic, hydrogen, and π-π bonding) between the functional monomer and the target compound used as the template.…”

Section: Introductionmentioning

confidence: 99%

“…The MIP attached to the magnetic core and coated with a BSA layer showed higher adsorption capacity and selectivity, excluding approximately 99% of proteins from biological samples. 8 Several works have reported the analysis of bile acids using mass spectrometry. [14][15][16] However, there is no method for the simultaneous analysis of bile acids using RAMIP-BSA.…”

Section: Introductionmentioning

confidence: 99%

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Online restricted access molecularly imprinted solid-phase extraction coupled with liquid chromatography-mass spectrometry for the selective determination of serum bile acids

Silveira

Barbosa

Faria

et al. 2022

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Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer

et al. 2020

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The analysis of 17β‐estradiol with high sensitivity and selectivity is extremely relevant to control the impacts that this compound can cause on health and the environment. Thus, we describe the development and application of a magneto carbon paste electrode based on magnetic molecularly imprinted polymer (MCPE‐MMIP) for determination of 17β‐estradiol. The analyte adsorbed on the MMIP was immobilized on the electrode surface by magnetic capture. The morphological and structural characterization of the obtained MMIP suggests that the material was effectively synthesized. MCPE‐MMIP showed an improvement in the sensitivity for 17β‐estradiol detection when compared to electrode configurations in the absence of this material. The optimum conditions (0.10 mol L−1 phosphate buffer pH 7.0) were reached by differential pulse adsorptive stripping voltammetry (DPAdSV), in which the method presented linearity ranged from 0.06 to 175 μmol L−1 with limits of detection and quantification of 0.02 and 0.06 μmol L−1, respectively. The proposed sensor was applied effectively in the analysis of 17β‐estradiol in river water and raw milk samples, exhibiting excellent recovery values (between 96.20 and 104 %), which were confirmed by HPLC analysis.

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Synthesis and characterization of a new magnetic restricted access molecularly imprinted polymer for biological sample preparation

Cited by 20 publications

References 48 publications

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Online restricted access molecularly imprinted solid-phase extraction coupled with liquid chromatography-mass spectrometry for the selective determination of serum bile acids

Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer

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