Synthesis and characterization of 3-acetoxy-2-methyl-N-(phenyl)benzamide and 3-acetoxy-2-methyl-N-(4- methylphenyl)benzamide

2-Tiyofenasetik Asitten Türetilen Heterosiklik Amitler: Sentez, Karakterizasyon ve Antimikrobiyal Aktivitesinin Değerlendirilmesi

“…The precipitate was filtered off and washed several times with water to remove an excess of the heterocyclic amine derivative and triethylamine hydrochloride salt. The crude product was crystallized from THF/acetonitrile [18,19,20]. The stepwise synthesis illustrated in Figure 1.…”

Synthesis, crystal structure, spectroscopic features and Hirshfeld surfaces of 2-methyl-3-[(2-methylphenyl)carbamoyl]phenyl acetate

“…Moreover, amide-based compounds represent an important group of efficient chelating ligands (Strotmeyer et al, 2003;Sliva et al, 1997;Pavlishchuk et al, 2011;Gumienna-Kontecka et al, 2007). Recently, we synthesized and studied some new substituted secondary benzamide derivatives obtained as a result of the interaction of aniline-based compounds with acyl chlorides (Ç akmak et al, 2016;Kırca et al, 2018;Demir et al, 2015;Kansız, Ç akmak et al, 2018). Among them, 3-acetoxy-2methyl-N-(4-methoxyphenyl) benzamide was found to exhibit good antioxidant activity (Demir et al, 2015).…”

“…A search in the Cambridge Structural Database (CSD version 5.39, update of August 2018; Groom et al, 2016) for 3-acetoxy-N-phenylbenzamide derivatives gave three hits: 3-acetoxy-2methyl-N-(4-methylphenyl)benzamide (HEJBIK; Kırca et al, 2018), 3-acetoxy-2-methyl-N-phenylbenzamide and 3-acetoxy-2-methyl-N-(4-methoxyphenyl)benzamide (HEJBOQ and JUMCEB, respectively; both Demir et al, 2015). The structure of HEJBIK is especially close to that of the title compound: it also contains two molecules in an asymmetric unit and is isostructural to the title compound with the exception of one methyl group (2-Me in the title compound and 4-Me in HEJBIK).…”

“…The synthesis was performed according to the reaction scheme presented in Fig. 8 and applied earlier for the synthesis of analogous compounds (Cakmak et al, 2016;Kırca et al, 2018, Demir et al, 2015. A solution of 3-acetoxy-2-methylbenzoyl chloride (11 mmol) in THF (10 mL) was added dropwise to a solution of 2-methylaniline (10 mmol) and triethylamine (10 mmol) in THF (10 mL) at room temperature.…”

Crystal Structure of 3-Acetoxy-2-methyl-<i>N</i>-(4-nitrophenyl)benzamide

“…The molecular structures of synthesized compounds have also been determinated by an x-ray diffraction method. [1][2][3][4] In this research 3-acetoxy-2-methyl-N-(4-nitrophenyl)benzamide ( Fig. 1) was prepared using a solution of 3-acetoxy-2-methylbenzoyl chloride (10 mmol) in THF (5 mL), which was added dropwise to a solution of 4-nitroaniline (10 mmol) and triethylamine (10 mmol) in THF (5 mL) at room temperature.…”