Synthesis and characterization of 2-hydroxyethyl methacrylate-ethylene glycol dimethacrylate polymeric granules intended for selective removal of uric acid

Leshchinskaya, A. P.; Ezhova, N. M.; Писарев, О. А.

doi:10.1016/j.reactfunctpolym.2016.02.014

Cited by 16 publications

(4 citation statements)

References 27 publications

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“…The greatest value of K F for HXL poly(AN-co-EGDMA-co-VBC) (HP4) among these polymers suggested the most efficient adsorption of salicylic acid. In the case of mefenamic acid, good correlation coefficient of the Langmuir model suggested that the experimental data are in better agreement with the Langmuir model implying monolayer adsorption onto an adsorbent surface [18,49], where one molecule can be adsorbed on one active site [49]. The linear Langmuir [20] and Freundlich [50,51] isotherm are described by the following equations, respectively:…”

Section: Adsorption Isothermmentioning

confidence: 84%

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption

et al. 2020

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Ethylene glycol dimethacrylate (EGDMA) is used as a crosslinker in poly(acrylonitrile (AN)-co-vinylbenzyl chloride (VBC)) to investigate the effect of long-chain crosslinker to the porosity of the terpolymer system. Poly(AN-co-EGDMA-co-VBC) is synthesized by using precipitation polymerization method and further hypercrosslinked by Friedel-Crafts reaction. FT-IR spectra of poly(AN-co-EGDMA-co-VBC) show that the absorption bands at ~1290 cm−1 that are assigned to the C–Cl vibrations are almost disappeared in hypercrosslinked (HXL) poly(AN-co-EGDMA-co-VBC) polymers, confirming that the hypercrosslinking reaction is successful. SEM images show that the morphologies of the polymers are retained through the hypercrosslinking reactions. Brunauer–Emmett–Teller (BET) analysis shows that hypercrosslinked polymers had a specific surface area up to 59 m2·g−1. The preliminary performance of the terpolymer adsorbent to capture polar analyte is evaluated by adsorbing salicylic acid and mefenamic acid from aqueous solution in a batch system. The maximum adsorption capacity of salicylic acid and mefenamic acid were up to 416.7 mg·g−1 and 625 mg·g−1, respectively, and the adsorption kinetic data obeyed pseudo-second-order rate equation.

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Section: Adsorption Isothermmentioning

confidence: 84%

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption

et al. 2020

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“…The applications of cryogel matrices in the immobilization of biomolecules, capture of target molecules, controlled drug release, cell separation, scaffolding, and in bioreactors afford new avenues for their biotechnological use. PHEMA is a well-known and FDA-approved acrylate polymer with many applications including contact lenses, drug delivery, separation, and implants [ 22 , 23 , 24 ]. Allyl glycidyl ether has a pendant epoxy group with allylic ether.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of a New Cryogel Matrix for Covalent Immobilization of Catalase

Altunbaş

Aslan

Kuşat

et al. 2022

Gels

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The advantages of cryogels for enzyme immobilization applications include their mechanical and chemical robustness, ease of production, superior porosity, and low cost. Currently, many researchers are exploring porous material-based systems for enzyme immobilization that are more efficient and economically viable. Here, poly(2-Hydroxyethyl methacrylate-co-allyl glycidyl ether) (p(HEMA-co-AGE)) cryogel matrices were synthesized via the free radical cryopolymerization method to be employed as the support material. For the immobilization of the catalase enzyme onto the p(HEMA-co-AGE) cryogel matrix (catalase@p(HEMA-co-AGE), the best possible reaction conditions were determined by altering parameters such as pH, catalase initial concentration, and flow rate. The maximum catalase immobilization amount onto the p(HEMA-co-AGE) cryogel was found to be 48 mg/g cryogel. To determine the advantages of the cryogel matrix, e.g., the stability and reusability of the cryogel matrix, the adsorption–desorption cycles for the catalase enzyme were repeated five times using the same cryogel matrix. At the end of the reusability tests, it was found that the cryogel was very stable and maintained its adsorption capacity with the recovery ratio of 93.8 ± 1.2%. Therefore, the p(HEMA-co-AGE) cryogel matrix affords repeated useability, e.g., up to five times, without decreasing its catalase binding capacities significantly and has promising potential for many industrial applications. Cryogels offer clear distinctive advantages over common materials, e.g., micro/nano particles, hydrogels, films, and composites for these applications. At present, many researchers are working on the design of more effective and economically feasible, porous material-based systems for enzyme immobilization

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“…To get solutions to better manage gout disease, several researchers developed various adsorbent materials able to remove purines and related compounds. Among them, microporous polymer granule [107], zinc oxide nanoparticles loaded on activated carbon [106] and polyethyleneimine/SiO 2 [108] were developed, and their potential to remove uric acid from blood sample, preventing the excessive serum uric acid content, was tested. For instance, the adsorption of uric acid onto zinc oxide nanoparticles loaded on activated carbon (ZnO-NP-AC) was studied, and the efficacy of this adsorbent was proven [106].…”

Section: Adsorption Methodsmentioning

confidence: 99%

Towards the Use of Adsorption Methods for the Removal of Purines from Beer

Almeida

Neves

2021

Molecules

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Beer corresponds to a fermented alcoholic beverage composed of several components, including purine compounds. These molecules, when ingested by humans, can be catabolized into uric acid, contributing to uric acid’s level increase in serum, which may lead to hyperuricemia and gout. To assure a proper management of this disease, physicians recommend restrictive dietary measures, particularly by avoiding the consumption of beer. Therefore, it is of relevance to develop efficient methods to remove purine compounds from alcoholic beverages such as beer. In this review, we provide an introduction on fermented alcoholic beverages, with emphasis on beer, as well as its purine compounds and their role in uric acid metabolism in the human body in relation to hyperuricemia and gout development. The several reported enzymatic, biological and adsorption methods envisaging purine compounds’ removal are then reviewed. Some enzymatic and biological methods present drawbacks, which can be overcome by adsorption methods. Within adsorption methods, adsorbent materials, such as activated carbon or charcoal, have been reported and applied to beer or wort samples, showing an excellent capacity for adsorbing and removing purine compounds. Although the main topic of this review is on the removal of purine compounds from beer, other studies involving other matrices rather than beer or wort that are rich in purines are included, since they provide relevant clues on designing efficient removal processes. By ensuring the selective removal of purine compounds from this beverage, beer can be taken by hyperuricemic and gouty patients, avoiding restrictive dietary measures, while decreasing the related healthcare economic burden.

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Synthesis and characterization of 2-hydroxyethyl methacrylate-ethylene glycol dimethacrylate polymeric granules intended for selective removal of uric acid

Cited by 16 publications

References 27 publications

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption

Synthesis and Characterization of a New Cryogel Matrix for Covalent Immobilization of Catalase

Towards the Use of Adsorption Methods for the Removal of Purines from Beer

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