Synthesis and characterisation of zinc oxide nanoparticles using terpenoid fractions of Andrographis paniculata leaves

Abstract

Zinc oxide (ZnO) nanoparticles have been widely employed for various pharmacological applications. Several approaches were tried to synthesize ZnO nanoparticles. In this study, ZnO nanoparticles were biosynthesized using terpenoid (TAP) fractions isolated from Andrographis paniculata leaves. Subsequently, the ZnNO 3 (0.1 N) is treated with the isolated TAP fractions to biosynthesize zinc oxide nanoparticles (Zn-TAP NPs). This nanoparticle preparation has been confirmed by the colour change from green to cloudy-white and the peak at 300 nm by UV-Visible spectra. FTIR analysis of Zn-TAP NPs showed the presence of functional group (i.e.) C=O which has further been confirmed by H 1 -NMR studies. From SEM and XRD analysis, it has been found that the hexagonal nanorod particle is 20.23 nm in size and ?17.6 mV of zeta potential. Hence, it can be easily absorbed by negatively charged cellular membrane to contribute for efficient intracellular distribution. Therefore, it is suggested that the synthesised Zn-TAP NPs are more suitable in drug delivery processes.

Biosynthesis of Zinc Oxide Nanoparticles from Acacia nilotica (L.) Extract to Overcome Carbapenem-Resistant Klebsiella Pneumoniae

“…Moreover, some of the bacterial cells were shown to change shape from rod-shaped to slightly coccus-shaped, while others decreased in size or showed multiple dents on the cell surface ( Figure 3 D–F). The SEM findings are consistent with those reported previously [ 16 , 17 , 18 ].…”

“…The morphological changes of KPC before and after treatment were evaluated by SEM imaging. The results showed transformations in cell size and shape due to the effect of ZnO-NPs; these changes led to the loss of the integrity of the membrane and the death of the cell [ 16 ]. The most interesting finding was obtained in vivo because it confirmed the potential of ZnO-NPs to overcome KPC.…”

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

“…Highly monodispersed (18.24 nm) spherical Au NPs could be synthesized using kaempferol as the in situ reductant and stabilizer [ 141 ]. The ability of terpenoid fractions isolated from Andrographis paniculata leaves for the green synthesis of ZnO NPs has also been demonstrated and confirmed by the presence of C=O functional group in the NPs [ 142 ]. Au NPs were synthesized using chlorogenic acid as reductant, and the corresponding FT-IR spectra indicated that an –OH functional group was likely involved in the synthesis [ 143 ].…”

Green Synthesis of ZnO Nanoparticles using Jasminum Fluminense Leaf Extract and its Spectral and Optical Characterization Studies

“…It is known that the ZnO nanoparticles have free electrons due to which Surface Plasmon Resonance (SPR) absorption band appear at 289.9 nm. This absorption peak indicates the reduction of Zn 2+ ions in the reaction medium which authenticates the formation of ZnO nanoparticles [4,11]. No other peaks have been observed which confirms the The energy band gap value is found to be 4.28 eV which is more than pure ZnO nanoparticles i.e., 3.4 eV.…”