Synthesis and characterisation of zein–curcumin colloidal particles

Patel, Ashok R.; Hu, Yingchun; Tiwari, Jyoti; Velikov, Krassimir P.

doi:10.1039/c0sm00800a

Cited by 425 publications

(284 citation statements)

References 36 publications

(44 reference statements)

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“…This behavior was also found by other authors when encapsulating curcumin in yeast cells of Saccharomyces cerevisiae by a diffusion method [21] . The same occurred in the case of spray drying encapsulation using porous starch and gelatin as encapsulants [22] and anti-solvent precipitation using zein as encapsulant [23] . Results indicate that there is a maximum amount of curcumin that can be encapsulated and the excess is removed from the dichloromethane-PLLA system during the solvent evaporation step forming the micrometric crystals observed in Figure 1.…”

Section: Silva-buzanello R a Souza M F Oliveira D A Bonamentioning

confidence: 99%

Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation

et al. 2016

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SbstractEncapsulation of bioactive compounds has been carried out to improve bioavailability and to protect them against harm conditions. However, encapsulation processes are often aggressive and it is important that encapsulated substances keep their biological activity. In this work curcumin was nanoencapsulated using dichloromethane as solvent and ultrasound as dispersion device. Nanoparticles were obtained using different curcumin concentrations and encapsulants (PLLA and Eudragit S100) and the encapsulation efficiency was inferred using spectroscopic and calorimetric techniques as well as optical microscopy. Total phenolic contents and antioxidant activity tests were applied to the curcumin before and after encapsulation and also to blank polymer nanoparticles. Results demonstrated that the encapsulation process had no deleterious influence on its antioxidant activity.

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Section: Silva-buzanello R a Souza M F Oliveira D A Bonamentioning

confidence: 99%

Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation

et al. 2016

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“…3 The poor solubility of curcumin limits its absorption and results in low bioavailability. 4 Many new drug delivery systems have been developed to increase the aqueous solubility and the bioavailability of curcumin by using a variety of drug carriers, including liposomes, 5 phospholipid, 6 cyclodextrin, 7 chitosan nanoparticles, 8 protein nanoparticles such as silk fibroin, 9 zein, 10 and bovine serum albumin, 11 synthetic polymer nanoparticles such as PLGA, 12,13 PCL-PEG-PCL triblock copolymer, 14 and polymer nanofibers such as polyvinyl alcohol (PVA), 15 poly-(ε-caprolactone), 16 and zein. 17 Another approach for improving the bioavailability of poorly water-soluble drugs is the micronization of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Zhao¹,

Xie²,

Li³

et al. 2015

IJN

135

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In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO 2 ) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 2 4 full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35°C, flow rate of solution =0.5 mL·min −1 , concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 μg/mL vs 0.2 μg/mL in 180 minutes). This study revealed that supercritical CO 2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.

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“…These particles have potential applications as delivery systems for drugs (1), nutraceuticals (3,4), antimicrobials (5), essential oils (6), as biomaterials in tissue engineering as scaffolds (7), and as biomedical coatings for arterial/vascular prostheses (8). Zein and kafirin are natural, plant based, non-allergenic, slowly biodegradable and have some advantages over animal based biomaterials such as silk and collagen, especially for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Modification of Kafirin Microparticles and Their Ability To Bind Bone Morphogenetic Protein-2 (BMP-2), for Application as a Biomaterial

Anyango

Duneas²,

Taylor

2012

J. Agric. Food Chem.

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Vacuolated spherical kafirin microparticles mean diameter 5 µm, can be formed from an acidic solution with water addition. Three dimensional scaffolds for hard tissue repair require large structures with a high degree of interconnected porosity. Cross-linking the formed kafirin microparticles using wet heat or glutaraldehyde treatment resulted in larger structures (approx. 20 µm), which whilst similar in size and external morphology, were apparently formed by further assisted-assembly by two significantly different mechanisms. Heat treatment, which increased vacuole size, involved kafirin polymerization by disulfide bonding with the microparticles being formed from round, coalesced nanostructures, as shown by AFM. Kafirin polymerization of glutaraldehyde treated microparticles was not by disulfide bonding and the nanostructures, as revealed by AFM, were spindle shaped. Both treatments enhanced BMP-2 binding to the microparticles, probably due to their increased size. Thus, these modified kafirin microparticles have potential as natural, non-animal protein bio-active scaffolds.

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Synthesis and characterisation of zein–curcumin colloidal particles

Cited by 425 publications

References 36 publications

Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation

Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Physicochemical Modification of Kafirin Microparticles and Their Ability To Bind Bone Morphogenetic Protein-2 (BMP-2), for Application as a Biomaterial

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