Synthesis and characterisation of thermo-responsive poly(N,N′-diethylacrylamide) microgels

Panayiotou, Marilia; Pöhner, Claudia; Vandevyver, Caroline; Wandrey, Christine; Hilbrig, Frank; Freitag, Ruth

doi:10.1016/j.reactfunctpolym.2006.12.008

Cited by 51 publications

(27 citation statements)

References 58 publications

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“…Microspheres were prepared by SFEP according to references (Leung et al, 2004;Panayiotou et al, 2007). In particular, DEA (1.0 g) and MAA (25 L) monomer and crosslinker (NNMBA) (0.03 g) were dissolved in 35 mL water in a round-bottomed flask equipped with a condenser, a nitrogen inlet, and a stirrer.…”

Section: Synthesis Of Core-shell Type Microspheresmentioning

confidence: 99%

“…Microparticles and nanoparticles based on core-shell structures are advantageous in terms of their long circulation in the body in addition to drug solubility, stability and high level of drug encapsulation. As the representative one, poly(N,N-diethylacrylamide) (PDEA) is a typical temperature-sensitive polymer, which exhibits a lower critical solution temperature (LCST) at about 28-30 • C (Marilia and Ruth, 2005;Panayiotou et al, 2007). Below the LCST, the polymer chains are soluble in water due to the formation of hydrogen bonds between the water molecules and the amide side chains.…”

Section: Introductionmentioning

confidence: 99%

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In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core–shell hydrogel microspheres

Liu

et al. 2010

International Journal of Pharmaceutics

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Section: Synthesis Of Core-shell Type Microspheresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core–shell hydrogel microspheres

Liu

et al. 2010

International Journal of Pharmaceutics

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“…PDEAAm is however considered more suited to applications in the life sciences, than PNIPAAm. It has been reported that cytotoxicity for PNIPAAm samples was more pronounced than for PDEAAm ones; with both prepared in a similar fashion [10]. The LCST of PDEAAm is not always favourable for biomedical applications since the physiological temperature is around 37°C, and a desired critical temperature for biomedical application should be at or near this temperature.…”

Section: Introductionmentioning

confidence: 99%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

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Novel thermo-sensitive N,N-diethylacrylamide (DEAAm) based copolymer hydrogels were prepared via UV-induced free radical bulk polymerisation. UV polymerisation was employed to avoid the use of potentially toxic solvents; solution polymerisation has been the most common means for the preparation of PDEAAm-based hydrogels in the literature to date. The resultant hydrogels were analysed using nuclear magnetic resonance, Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. Parameters such as the crosslinking degree and the nature of the incorporated hydrophilic component, N-vinyl-2-pyrrolidone (NVP) or N,N-dimethylacrylamide (DMAAm) were found to impact hydrogel structure, mechanical properties and swelling kinetics. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties which were greatly affected by test temperature, nature of hydrophilic monomer used and crosslinker content. Aminophylline was selected as a model solute for drug loading and release studies by thermal deswelling in HCl buffer (pH 1.4) and phosphate buffer media (pH 6.8). The observed lag time prior to significant drug release from the more crosslinked P(DEAAm-NVP) hydrogels could make them suitable for delayed specific release in the intestine and potential alternatives to layers or membranes in timespecific and site-specific swelling-controlled drug delivery systems.

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“…Monodisperse PNIPAAm microgels were obtained by using persulfate initiator and N, N -methylene bisacrylamide (BIS) as crosslinker. Freitag and coworkers reported surfactant-free synthesis of thermoresponsive poly(N,N -diethylacrylamide) (PNDEAm) microgels [55]. In their study, the influence of the stirring rate on the microgel size was investigated.…”

Section: Surfactant-free Synthesismentioning

confidence: 99%

Microgels by Precipitation Polymerization: Synthesis, Characterization, and Functionalization

Pich

Richtering

2010

Advances in Polymer Science

200

206

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This chapter reviews recent work on the synthesis of aqueous microgel particles by precipitation polymerization. Precipitation polymerization allows flexible control over important physicochemical properties of aqueous microgels, such as size distribution, surface charge, chemical composition, and microstructure. The microgel systems discussed in this review are mainly based on poly(N-isopropyl acrylamide) and poly(N-vinylcaprolactam) due to their ability to react to external stimuli such as the pH or temperature of the surrounding medium. We discuss synthetic routes to obtain microgels based on homo-or copolymers as well as colloids with complex core-shell morphology. The functionalization of microgels is of crucial importance from the application point of view. Different routes for incorporation of functional groups, synthetic polymers, proteins, or nanoparticles in microgel structures are discussed.

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Synthesis and characterisation of thermo-responsive poly(N,N′-diethylacrylamide) microgels

Cited by 51 publications

References 58 publications

In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core–shell hydrogel microspheres

In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core–shell hydrogel microspheres

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Microgels by Precipitation Polymerization: Synthesis, Characterization, and Functionalization

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