Synthesis and Characterisation of Some Novel Indeno[1,2-c]pyrazoles

Abstract

1-(Benzothiazol-2-yl)-4-phenylindeno [1,2-c]pyrazoles (1) and 1-(4-arylthiazol-2-yl)-4-phenylindeno[1,2-c]pyrazoles (2) have been synthesised by the reaction between 1-oxo-3-phenylindan-2-carboxaldehyde (4) and 2-hydrazinobenzothiazoles or 2-hydrazinothiazoles.

Novel regioselective synthesis of 4-isothiocyanatobutan-2-one by a Staudinger reaction. preparation of 6-unsubstituted 4-hydroxyhexahydropyrimidine-2-thiones

“…It should be noted that the yields of pyrimidines 6, 7 reported in the literature [10][11][12][13] are markedly below those obtained in our work. This was shown by us in the conversion of this compound to the hydroxypyrimidine 6 by treatment of a solution of isothiocyanate 2 in acetonitrile at 20ºC for 1 h with aqueous ammonia (1.5 eq.…”

Virtual screening and molecular docking of structures with potential inhibitor of the ebolavirus glycoprotein

“…The ZINC1 showed a score of 0.8 in the retrosynthesis obtained from the SPAYA server, the theoretical synthesis of the compound (Figure 15) starts with the production of forfural (I), it can be obtained from the dehydration of xylose (Mamman et al, 2008;Zeitsch, 2000), may also occur by the putative mechanism for the acid-catalyzed dehydration of xylose, in which displacement of the protonated C-2 hydroxyl group leads to a 2,5-anhydride intermediate which dehydrates to furfural (Nimlos et al, 2006;Antal Jr et al, 1991). Subsequently, it is necessary to obtain the compound 1,3-thiazolidin-2-ylhydrazine (II) from 1,3-thiazol-2-amine following the reaction observed in Singh et al, (2005). The ZINC1 molecule can be obtained in Source: Own Authorship.…”

Pyrazole‐Clubbed Piperazinyl Urea Derivatives: Synthesis, Characterization and Antimicrobial Studies toward Generating an Antibiotic/Antifungal Resistance Sensor

“…In recent years, the molecular‐hybrid approach involving two or more pharmacophores bound together covalently in one molecular framework has been resulted in the development of a number of bioactive hybrid molecules [33] . Due to exhibiting a wide range of approved biological activities, the flourishment of new chemical entities (NCE's) possessing pyrazole ring has very much attracted researchers over the past several decades [34–40] …”