Synthesis and characterisation of silica nanoparticles bearing different functional groups obtained <i>via</i> a two‐stage method

Berriozabal, Gemma; Miguel, Yolanda R. de

doi:10.1002/pssc.200983837

Cited by 12 publications

(4 citation statements)

References 13 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drugs can easily be accommodated in the space of interlayers by ion exchange as compared to the other nanoparticles which need surface modification i.e. functionalization of the surface [11,12]. …”

Section: Introductionmentioning

confidence: 99%

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Saifullah

Hussein

Hussein‐Al‐Ali

et al. 2013

Chemistry Central Journal

View full text Add to dashboard Cite

BackgroundTuberculosis (TB), is caused by the bacteria, Mycobacterium tuberculosis and its a threat to humans since centuries. Depending on the type of TB, its treatment can last for 6–24 months which is a major cause for patients non-compliance and treatment failure. Many adverse effects are associated with the currently available TB medicines, and there has been no new anti-tuberculosis drug on the market for more than 50 year, as the drug development is very lengthy and budget consuming process.Development of the biocompatible nano drug delivery systems with the ability to minimize the side effects of the drugs, protection of the drug from enzymatic degradation. And most importantly the drug delivery systems which can deliver the drug at target site would increase the therapeutic efficacy. Nanovehicles with their tendency to release the drug in a sustained manner would result in the bioavalibilty of the drugs in the body for a longer period of time and this would reduce the dosing frequency in drug administration. The biocompatible nanovehicles with the properties like sustained release of drug of the target site, protection of the drug from physio-chemical degradation, reduction in dosing frequency, and prolong bioavailability of drug in the body would result in the shortening of the treatment duration. All of these factors would improve the patient compliance with chemotherapy of TB.ResultAn anti-tuberculosis drug, 4-amino salicylic acid (4-ASA) was successfully intercalated into the interlamellae of zinc layered hydroxide (ZLH) via direct reaction with zinc oxide suspension. The X-ray diffraction patterns and FTIR analyses indicate that the molecule was successfully intercalated into the ZLH interlayer space with an average basal spacing of 24 Å. Furthermore, TGA and DTG results show that the drug 4-ASA is stabilized in the interlayers by electrostatic interaction. The release of 4-ASA from the nanocomposite was found to be in a sustained manner. The nanocomposite treated with normal 3T3 cells shows it reduces cell viability in a dose- and time-dependent manner.ConclusionsSustained release formulation of the nanocomposite, 4-ASA intercalated into zinc layered hydroxides, with its ease of preparation, sustained release of the active and less-toxic to the cell is a step forward for a more patient-friendly chemotherapy of Tuberculosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Saifullah

Hussein

Hussein‐Al‐Ali

et al. 2013

Chemistry Central Journal

View full text Add to dashboard Cite

show abstract

“…Among these are their ease of laboratory preparation with a controlled particle size, 16 and the drugs can be easily loaded into the interlayers space by ion exchange, comparing with other nanoparticles which need further modification such as surface functional modification. 17,18 Layered double hydroxides have a high zeta potential, 20-30 mV, which provides a strong driving force on to the surface of a cell. LDH are degraded in an acidic environment to form M 2+ , M 3+ , and X -ions which leads the drug actives leaving the cell through the ion-tunnels, whereas the others inorganic nanoparticles accumulate in the cells because of their low solubility in the cells.…”

Section: Introductionmentioning

confidence: 99%

Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

Ali¹,

Zainal²,

Hakim³

et al. 2011

IJN

View full text Add to dashboard Cite

An ellagic acid (EA)–zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8′ position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host–guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

show abstract

“…The size distribution of the nanosilica particles was determined using the Zetasizer Nano ZS90 device (Malvern Panalytical, Malvern, UK), which determines the size by the hydrodynamic diameter and has already been used in other similar studies for the same purpose [ 22 , 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Analysis of the Microstructure and Porosity of Cement Pastes with Functionalized Nanosilica with Different Contents of Aminosilane

Martins,

Fraga,

de Paula

et al. 2023

Materials

View full text Add to dashboard Cite

This research aims to analyze the effect of functionalized nanosilica (NSF) with different levels of amine groups in the formation of hydration products. Four cement pastes were investigated, one reference with Portland cement and three replacing 1% of Portland cement by nanosilica (NS), NSF with a low content of amine groups, and NSF with a high content of amine groups. The heat of hydration of the pastes was evaluated up to 7 days of hydration, the amount of calcium hydroxide (CH) and hydrated phases by means of the thermogravimetric analysis (TGA) test and compressive strength at 2, 7, and 28 days, and porosity through tests of mercury intrusion porosimetry and computed tomography at 28 days of hydration. It was possible to observe that the NSF directly influenced the hydration kinetics of the pastes, delaying the hydration of the Portland cement; however, it demonstrated a similar mechanical performance to the paste with NS at 2 days of hydration and an increase of 10% at 28 days of hydration due to the improvement in the hydration process. Thus, it is possible to conclude that the functionalization of NSF with a low 3-aminopropyltriethoxysilane (APTES) content is promising for use in cementitious materials and may improve hydration and mechanical performance at more advanced ages compared to NS.

show abstract

Synthesis and characterisation of silica nanoparticles bearing different functional groups obtained via a two‐stage method

Cited by 12 publications

References 13 publications

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

Analysis of the Microstructure and Porosity of Cement Pastes with Functionalized Nanosilica with Different Contents of Aminosilane

Contact Info

Product

Resources

About