Synthesis and characterisation of poly(glycerol sebacate)-co-lactic acid as surgical sealants

Chen, Qizhi; Liang, Sophie Hsin-Yi; Thouas, George Anthony

doi:10.1039/c1sm05350g

Cited by 64 publications

(58 citation statements)

References 35 publications

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“…For example, Chen et al . developed a surgical sealant based on poly(glycerol sebacate) (PGS) and lactic acid (LA) [3]. The use of LA improved the cytocompatibility of the engineered sealant compared to PGS alone.…”

Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 99%

“…The sealant could be applied at 45 °C and solidified at 37 °C to form an elastic gel by exposing to a cold gas. It was shown that the fabricated sealant had higher adhesion strength to the tissues compared to both fibrin glues and synthetic sealants such as Pleuraseal [3]. Photocurable elastomers based on PGS with strain between 42–189% and Young Modulus of 0.05–1.38 MPa were also developed through acrylation of PGS [21].…”

Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 99%

“…Recently, extensive research efforts have been made to engineer biocompatible, biodegradable, and flexible sealants for the formation of leak-free closures in soft tissues [3–5]. The sealant materials are required to be elastic and compliant to allow normal function and movement of elastic native tissues such as lungs, skin, blood vessel, and heart tissues.…”

Section: Introductionmentioning

confidence: 99%

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Elastic sealants for surgical applications

Annabi

Yue

Tamayol

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

197

176

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Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.

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Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 99%

Section: Synthetic Polymer Derived Elastic Sealantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elastic sealants for surgical applications

Annabi

Yue

Tamayol

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

197

176

View full text Add to dashboard Cite

show abstract

“…Polyglycerol sebacate (PGS), a biodegradable elastomer, has been extensively evaluated for a broad range of applications in regenerative medicine including cardiovascular patches (Chen et al , 2008), vascular tissue grafts (Motlagh et al , 2006), engineered heart valves (Masoumi et al , 2013), cartilage tissues (Kemppainen and Hollister, 2010), nerve conduits (Sundback et al , 2005), retinal implants (Pritchard et al , 2010), and surgical sealants (Chen et al , 2011). Such diverse applications are primarily attributed to the controlled degradation profile, non-toxic byproducts and highly elastomeric nature of PGS (Rai et al , 2012; Wang et al , 2003a; Wang et al , 2002).…”

Section: Introductionmentioning

confidence: 99%

Anisotropic poly (glycerol sebacate)-poly (ϵ-caprolactone) electrospun fibers promote endothelial cell guidance

et al. 2014

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Topographical cell guidance is utilized to engineer highly organized and aligned cellular constructs for numerous tissue engineering applications. Recently, electrospun scaffolds fabricated using poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL) have shown a great promise to support valvular interstitial cell functions for the development of tissue engineered heart valves. However, one of the major drawbacks of PGS-PCL scaffolds is the lack of control over cellular alignment. In this work we investigate the role of scaffold architecture on the endothelial cell alignment, proliferation and formation of organized cellular structures. In particular, PGS-PCL scaffolds with randomly oriented and highly aligned fibers with tunable mechanical properties were fabricated using electrospinning technique. After one week of culture, endothelial cells on the aligned scaffolds exhibit higher proliferation compared to those cultures on randomly oriented fibrous scaffolds. Furthermore, the endothelial cells reorganize in response to the topographical features of anisotropic scaffolds forming highly organize cellular constructs. Thus, the topographical contact guidance, provided by aligned PGS-PCL scaffolds, is envisioned to be useful in developing aligned cellular structures for vascular tissue engineering.

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“…PGS is the most widely studied PPS member [4,8,[21][22][23][24]. The Young's modulus of PGS is in the range of 0.05-1.5MPa [25].…”

Section: Introductionmentioning

confidence: 99%

A comparative study on poly(xylitol sebacate) and poly(glycerol sebacate): mechanical properties, biodegradation and cytocompatibility

Li¹,

Huang²,

Cook³

et al. 2013

Biomed. Mater.

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In order to develop degradable elastomers with a satisfactory combination of flexibility and enzyme-mediated degradation rate, the mechanical properties, enzymatic degradation kinetics and biocompatibility of poly(xylitol sebcate) (PXS) has been systematically investigated in comparison with poly(glycerol sebacate) (PGS). Under the same level of crosslinked density, the PXS elastomer networks have approximately twice the stretchability (elongation at break) of their PGS counterparts. This observation is attributable to the relatively longer and more orientable xylitol monomers, compared with glycerol molecules. Although xylitol monomers have two more hydroxyl groups, we, surprisingly, found that the hydrophilic side chains did not accelerate the water attack on the ester bonds of the PXS network, compared with their PGS counterpart. This observation was attributed to a steric hindrance effect, i.e. the large-sized hydroxyl groups can shield ester bonds from the attack of water molecules. In conclusion, the use of polyols of more than three -OH groups is an effective approach enhancing flexibility, whilst maintaining the degradation rate of polyester elastomers. Further development could be seen in the copolymerization of PPS with appropriate thermoplastic polyesters, such as poly(lactic acid) and polyhydroxyalkanoate.

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Synthesis and characterisation of poly(glycerol sebacate)-co-lactic acid as surgical sealants

Cited by 64 publications

References 35 publications

Elastic sealants for surgical applications

Elastic sealants for surgical applications

Anisotropic poly (glycerol sebacate)-poly (ϵ-caprolactone) electrospun fibers promote endothelial cell guidance

A comparative study on poly(xylitol sebacate) and poly(glycerol sebacate): mechanical properties, biodegradation and cytocompatibility

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