Synthesis and characterisation of morin reduced gold nanoparticles and its cytotoxicity in MCF-7 cells

Kondath, Sindhu; Raghavan, Bhuvanasree Srinivas; Rajaram, A.; Rajaram, Rama

doi:10.1016/j.cbi.2014.09.025

Cited by 40 publications

(30 citation statements)

References 61 publications

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“…Apoptosis induced by morin in human leukemia HL-60 cells can involve a mitochondria-dependent pathway and a caspase-3-mediated mechanism [62]. In the MCF-7 line of breast cancer cells, this pentahydroxyflavone can target cell proliferation via caspase-activated mitochondrial pathway or through independent pathways [63]. In a human leukemic cell line, morin treatment was observed to activate the caspase-dependent apoptosis in a dose-dependent mode.…”

Section: Phytochemical Compounds and Cancermentioning

confidence: 99%

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Budişan

Gulei

Zănoagă

et al. 2017

IJMS

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Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer. The aim of this paper is to review the recent studies regarding the role of these natural phytochemicals in different processes related to cancer inhibition, including apoptosis activation, angiogenesis and metastasis suppression. From the large palette of phytochemicals we selected epigallocatechin gallate (EGCG), caffeic acid phenethyl ester (CAPE), genistein, morin and kaempferol, due to their increased activity in modulating multiple coding and non-coding genes, targeting the main hallmarks of cancer.

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Section: Phytochemical Compounds and Cancermentioning

confidence: 99%

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Budişan

Gulei

Zănoagă

et al. 2017

IJMS

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“…Morin is a flavonoid from Moraceae that exhibits anti-proliferative and antitumor effects in ER-positive, ER-negative and PR-negative human breast cancer cell lines [223, 224]. Morin, a phytoestrogen, has the 7- and 4- positions occupied by hydroxy groups; these two positions correspond to the 3- and 4- positions of DES [225].…”

Section: Natural Products Against Er-positive Breast Cancermentioning

confidence: 99%

Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

Bak

Gupta

Wahler

et al. 2016

Seminars in Cancer Biology

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Estrogen receptor (ER)-positive breast cancer, including luminal-A and -B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer.

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“…In the past decade, nanoparticles have drawn attention of many researchers for their unique optical and chemical behaviors which can be easily changed by changeable the morphology [1][2][3]. Within the large family of metal nanoparticles, AuNPs have been used in various cutting edge applications such as biology systems and medicinal industry, communication, nano-electronics, nano-sensor and environmental protection [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Bioinspired synthesis, characterization and antifungal activity of enzyme-mediated gold nanoparticles using a fungal oxidoreductase

et al. 2016

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by disk diffusion method indicated a potent growth inhibitory activity against all tested human pathogenic yeasts and molds by inhibition zones ranged from 10 to 18 mm. Taken together, our enzymatically established method of nanoparticle synthesis using a purified sulfite oxidoreductase of F. oxysporum can be considered as an efficient tool for generating harmless bioactive gold nanoparticles with potential applications in biology, medicine and industry.

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Synthesis and characterisation of morin reduced gold nanoparticles and its cytotoxicity in MCF-7 cells

Cited by 40 publications

References 61 publications

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

Bioinspired synthesis, characterization and antifungal activity of enzyme-mediated gold nanoparticles using a fungal oxidoreductase

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