Synthesis and characterisation of Co(iii) complexes of N-formyl hydroxylamines and antibacterial activity of a Co(iii) peptide deformylase inhibitor complex

Abstract

Bidentate (O,O′) N-formylhydroxylamine chelation of Co(iii) centres and notable antibacterial activity of a Co(iii) peptide deformylase inhibitor complex against sensitive and resistant strains of S. aureus.

Discovery of Inhibitors for Mycobacterium Tuberculosis Peptide Deformylase Based on Virtual Screening in Silico

“…M. tuberculosis PDF( Mt PDF) is of vital importance for the growth and survival of M. tuberculosis , which makes it an attractive target for antituberculotic drug development [13] . Some inhibitors for PDF have been subjected to clinical trials as antibacterial agents [14] . However, inhibitors for Mt PDF as antituberculotic agents remain to be further studied.…”

“…[13] Some inhibitors for PDF have been subjected to clinical trials as antibacterial agents. [14] However, inhibitors for MtPDF as antituberculotic agents remain to be further studied. The chemicals with potent inhibition on MtPDF bear the general structures as shown in Figure 1: X represents the pharmacophores for chelating a metal ion to provide the primary binding energy; P1' of n-butyl mimics the methionine side chain of the natural ligand; P2' and P3' represent variable substitutions that capable of providing additional binding energies, selectivity, and pharmaco-kinetic characteristics.…”