Synthesis and characterisation of chitosan-encapsulated genistein: its anti-proliferative and anti-angiogenic activities

Rahmani, Fatemeh; Karimi, Ehsan; Oskoueian, Ehsan

doi:10.1080/02652048.2020.1740804

Cited by 26 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the years, various natural bioactive ingredients such as tea polyphenols [ 94 , 95 ], curcumin [ 96 ], flavonoids (e.g., genistein [ 97 ], baicalein and quercetin [ 98 ], kaempferol [ 99 ]), phenolic compounds [ 100 ] (e.g., ferulic acid [ 101 ]) have been encapsulated in chitosan nanoparticles.…”

Section: Chitosan As a Matrix For Nanosystemspreparation: Methodsmentioning

confidence: 99%

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

View full text Add to dashboard Cite

Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers’ formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

show abstract

Section: Chitosan As a Matrix For Nanosystemspreparation: Methodsmentioning

confidence: 99%

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In hepatic cellular carcinoma HepG2, Huh7 and Hep3B cell lines, pro-apoptotic influence of genistein was reported to be more pronounced than normal hepatic L-02 cells [ 44 ]. Likewise, chitosan-encapsulated genistein treatment in colon cancer HT-129 cells promoted anti-angiogenesis while the viability of normal cells was not effected in tested genistein concentrations [ 45 ]. Outcomes of these investigations highlight selective effect of genistein and suggests its therapeutic implementation for curbing human carcinogenicity.…”

Section: Introductionmentioning

confidence: 99%

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

et al. 2021

View full text Add to dashboard Cite

Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer. Emerging preclinical evidence have shown its anti-cancer, anti-inflammatory and anti-oxidant properties. Testing of this substance is in various phases of clinical trials. Comprehensive preclinical and clinical trials data is providing insight on genistein as a modulator of various signaling pathways both at transcription and translation levels. In this review we have explained the mechanistic regulation of several key cellular pathways by genistein. We have also addressed in detail various microRNAs regulated by genistein in different types of cancer. Moreover, application of nano-formulations to increase the efficiency of genistein is also discussed. Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.

show abstract

“…However, when this compound is administered orally, it has very low stability and bioavailability, due to its insolubility in water [ 11 , 32 ]. Therefore, its encapsulation could improve not only its bioavailability, but also its stability (against oxidizing agents) and its efficacy at the target site [ 33 ]. The choice of a good encapsulating agent will allow the compounds to move through the gastrointestinal system, without changes or loss of activity, and to be released at the specific site where the action of this chemopreventive agent is required.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Genistein In Vitro as a Chemopreventive Agent for Colorectal Cancer—Strategy to Improve Its Efficiency When Administered Orally

et al. 2022

View full text Add to dashboard Cite

Colorectal Cancer (CRC) ranks third in terms of incidence and second in terms of mortality and prevalence worldwide. In relation to chemotherapy treatment, the most used drug is 5-fluorouracil (5-FU); however, the use of this drug generates various toxic effects at the systemic level. For this reason, new therapeutic strategies are currently being sought that can be used as neoadjuvant or adjuvant treatments. Recent research has shown that natural compounds, such as genistein, have chemotherapeutic and anticancer effects, but the mechanisms of action of genistein and its molecular targets in human colon cells have not been fully elucidated. The results reported in relation to non-malignant cell lines are also unclear, which does not allow evidence of the selectivity that this compound may have. Therefore, in this work, genistein was evaluated in vitro in both cancer cell lines SW480 and SW620 and in the non-malignant cell line HaCaT. The results obtained show that genistein has selectivity for the SW480 and SW620 cell lines. In addition, it inhibits cell viability and has an antiproliferative effect in a dose-dependent manner. Increased production of reactive oxygen species (ROS) was also found, suggesting an association with the cell death process through various mechanisms. Finally, the encapsulation strategy that was proposed made it possible to demonstrate that bacterial nanocellulose (BNC) is capable of protecting genistein from the acidic conditions of gastric fluid and also allows the release of the compound in the colonic fluid. This would allow genistein to act locally in the mucosa of the colon where the first stages of CRC occur.

show abstract

Synthesis and characterisation of chitosan-encapsulated genistein: its anti-proliferative and anti-angiogenic activities

Cited by 26 publications

References 37 publications

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Evaluation of the Effects of Genistein In Vitro as a Chemopreventive Agent for Colorectal Cancer—Strategy to Improve Its Efficiency When Administered Orally

Contact Info

Product

Resources

About