Synthesis and characterisation of bioactive and antibacterial glass–ceramic Part 1 – Microstructure, properties and biological behaviour

Verné, Enrica; Ferraris, Sara; Miola, Marta; Fucale, Giacomo; Maina, Giovanni; Martinasso, Germana; Canuto, Rosa Angela; Nunzio, Serena Di; Brovarone, Chiara Vitale

doi:10.1179/174367508x306532

Cited by 34 publications

(26 citation statements)

References 41 publications

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“…Afterwards, some bacterial colonies were spread in normal saline (0.9% P/V of NaClin distilled water) to obtain a standard 0. plate. The number of dilution was chosen on the basis of previous works [18,19]. The blood-agar plates were incubated at 35°C and after 24 h, the CFU were counted; the obtained number was multiplied by the dilution factor in order to get the total number of CFU of the starting solution.…”

Section: Antibacterial Testsmentioning

confidence: 99%

Biocompatibility and Antibacterial Effect of Silver Doped 3D-Glass-Ceramic Scaffolds for Bone Grafting

et al. 2010

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A 3D-glass-ceramic scaffold for bone tissue engineering with an interconnected macroporous network of pores was doped with silver ions in order to confer antibacterial properties. For this purpose, silver ions were selectively added to the scaffold surfaces through ion-exchange using an aqueous silver nitrate solution. The silver-doped scaffolds were characterized by means of leaching, in vitro antibacterial, and citotoxicity tests. In particular, the silver effect was examined through a broth dilution test in order to evaluate the proliferation of bacteria by counting the colonies forming units. Moreover, cytotoxicity tests were carried out to understand the effect of silver-containing scaffolds on cell adhesion, proliferation, and vitality. For all tests a comparison between silver-doped scaffold and silver-doped scaffold dry sterilized was performed.

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Section: Antibacterial Testsmentioning

confidence: 99%

Biocompatibility and Antibacterial Effect of Silver Doped 3D-Glass-Ceramic Scaffolds for Bone Grafting

et al. 2010

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“…The same timetable in terms of bioactivity was observed for CEL2 scaffolds . Then, the presence of silver does not influence the bioactivity mechanism and kinetics, as already observed in previous works …”

Section: Discussionmentioning

confidence: 94%

“…11 Then, the presence of silver does not influence the bioactivity mechanism and kinetics, as already observed in previous works. 10,32 Leaching tests showed that silver was released with kinetics helpful to treat both the development of infections due to bacterial contamination (direct or indirect) of an implant throughout the surgery and the development of latent infections. Moreover, the total amount of silver released (about 0.035 mg) is extensively below the values that are considered toxic for healthy cells (about 0.1 mg for L929 fibroblasts).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Bioglass‐Derived Scaffolds: Innovative Synthesis Approach and Characterization

Miola

Verné

Vitale-Brovarone

et al. 2016

Int J of Appl Glass Sci

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Prevention and successful treatment of implant infection following bone surgery are critical challenges to avoid additional stress, disease, and any extra‐surgery to patients. We investigated the feasibility of a new synthesis method to prepare a bioactive glass‐ceramic scaffolds doped with silver, an antibacterial element. Scaffolds were fabricated by sponge replication method and silver was incorporated in the glass‐based slurry that infiltrates the template using silver nitrate as a precursor. The silver‐doped scaffolds mimic closely the cancellous bone in terms of 3‐D trabecular architecture and mechanical properties, were highly bioactive as demonstrated by the in vitro formation of a surface hydroxyapatite layer upon soaking in simulated body fluids, and exhibited good antibacterial properties against Staphylococcus aureus, a common bacterial strain involved in postsurgical infections.

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“…In this work the bioactive and ferrimagnetic SC45 was enriched with silver to impart antimicrobial properties, thus realizing a multifunctional glass-ceramic useful for the treatment of bone tumor and associated complications. Since it was already demonstrated by the authors that the introduction of a small amount of silver does not inhibit the bioactive behavior of a glass/glass-ceramic, or at least it can improve bioactivity [28,29,35,36], in this work the influence of the Ag introduction in the glass-ceramic composition was principally investigated in terms of structure, morphology, magnetic and antibacterial properties. The obtained glass-ceramic could be proposed as filler in polymeric-based bone cement or in other injectable materials for bone surgery that need to be improved with bioactive, magnetic and antibacterial properties by the presence of a single additional phase.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional ferrimagnetic glass–ceramic for the treatment of bone tumor and associated complications

et al. 2017

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Silver-containing ferrimagnetic glass-ceramic (Ag-SC45) was synthesized by means of melt and quenching technique. Samples were subjected to morphological, compositional, structural analyses, ability to generate heat, magnetic measurements at high and low magnetic field and antibacterial test using S. aureus strain. The influence of silver introduction and the effect of annealing process were investigated. Morphological, compositional and structural analyses evidenced the formation of metallic silver particles embedded in the glass-ceramic. The hysteresis cycles showed slight differences in the hysteresis cycle area ratio and coercive field values as a function of the annealing treatment and of silver presence, while no difference was evidenced in the specific power loss. All samples demonstrated the ability to produce heat when exposed to an alternating magnetic field. Finally, preliminary antibacterial test showed that Ag-SC45 samples not subjected to annealing possessed an antibacterial effect.

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Synthesis and characterisation of bioactive and antibacterial glass–ceramic Part 1 – Microstructure, properties and biological behaviour

Abstract: Synthesis and characterisation of bioactive and antibacterial glass-ceramic Part 1 -Microstructure, properties and biological behaviour / E.

Cited by 34 publications

References 41 publications

Biocompatibility and Antibacterial Effect of Silver Doped 3D-Glass-Ceramic Scaffolds for Bone Grafting

Biocompatibility and Antibacterial Effect of Silver Doped 3D-Glass-Ceramic Scaffolds for Bone Grafting

Antibacterial Bioglass‐Derived Scaffolds: Innovative Synthesis Approach and Characterization

Multifunctional ferrimagnetic glass–ceramic for the treatment of bone tumor and associated complications

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