2019
DOI: 10.3390/catal9100790
|View full text |Cite
|
Sign up to set email alerts
|

Synthesis and Catalytic Application of Knölker-Type Iron Complexes with a Novel Asymmetric Cyclopentadienone Ligand Design

Abstract: Asymmetric catalysis is an essential tool in modern chemistry, but increasing environmental concerns demand the development of new catalysts based on cheap, abundant, and less toxic iron. As a result, Knölker-type catalysts have emerged as a promising class of iron catalysts for various chemical transformations, notably the hydrogenation of carbonyls and imines, while asymmetric versions are still under exploration to achieve optimal enantio-selectivities. In this work, we report a novel asymmetric design of a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
13
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 16 publications
(13 citation statements)
references
References 76 publications
0
13
0
Order By: Relevance
“…The chiral complexes recently reported by De Wildeman and co‐workers and their applications in ketone AH …”
Section: Applications In Reactions Involving Ht Stepsmentioning
confidence: 99%
See 1 more Smart Citation
“…The chiral complexes recently reported by De Wildeman and co‐workers and their applications in ketone AH …”
Section: Applications In Reactions Involving Ht Stepsmentioning
confidence: 99%
“…Very recently, De Wildeman and co‐workers reported new chiral CICs possessing a C 2 ‐symmetric cyclopentadienone ligand with stereocenters at positions 2,5 – i.e., closer to the C=O group involved in the catalytic activity (Scheme ) . This kind of design led to a slight improvement in terms of enantioselectivity compared to the Wills' pre‐catalysts, although the ee values remained moderate.…”
Section: Applications In Reactions Involving Ht Stepsmentioning
confidence: 99%
“…Knölker-type iron complexes are known to efficiently catalyze hydrogen transfer reactions [ 86 ]; however, despite their wide application, this class of catalysts suffered from a poor stereocontrol. Recently, the design of a new Knölker-type catalyst L16 ·Fe(0)(CO) 3 , featuring a C2-symmetric cyclopentadienone ligand bearing chiral substituents at the 2 and 5 positions, provided ees up to 70% for the asymmetric hydrogenation of different ketones ( Scheme 31 ) [ 87 ].…”
Section: Othersmentioning
confidence: 99%
“…applied in ATH of ketones by De Wildeman et al were applied in AH of a range of ketones bearing alkyl and aryl or heteroaryl substituents (Scheme 36)[68]. The resulting alcohols were obtained with fair to high conversions and low to good enantioselectivities, some being among the highest obtained using chiral Knölker-type catalysts.…”
mentioning
confidence: 99%