Synthesis and biological studies of the [99mTc]tetrachloronitrosyltechnetium(II) anion—An alternative low valent technetium starting material

Cheah, Cheryl; Newman, Josephine; Nowotnik, David P.; Thornback, John R.

doi:10.1016/0883-2897(87)90028-6

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…The [TcCl 6 ] 2– counterion does not represent a decomposition product of the nitrosyl compound, but was contained in significant amounts in the starting material, which was prepared according to a not fully outlined literature procedure , . Such findings encouraged us to re‐investigate the synthesis of the common starting material (NBu 4 )[Tc II (NO)Cl 4 (MeOH)] with special attention to the complete removal of eventually formed hexachloridotechnetate(IV).…”

Section: Resultsmentioning

confidence: 99%

“…To the best of our knowledge, a detailed synthesis of this frequently used starting complex of the nitrosyl chemistry of technetium from pertechnetate and hydroxylamine hydrochloride has never been described. Usually, a procedure of Cheah et al is given as reference . In the corresponding publication, however, only the synthesis of the 99m Tc complex, that means at nanomolar concentrations of TcO 4 – , is reported.…”

Section: Resultsmentioning

confidence: 99%

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Nitrosyltechnetium(I) Complexes with 2‐(Diphenylphosphanyl)aniline

Ackermann

Noufele

Hagenbach

et al. 2018

Zeitschrift anorg allge chemie

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nitrosyltechnetium(I) Complexes with 2‐(Diphenylphosphanyl)aniline

Ackermann

Noufele

Hagenbach

et al. 2018

Zeitschrift anorg allge chemie

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“…[2-7] The preparation of [Bu 4 N][Tc(NO)Cl 4 ] involves reacting [Bu 4 N][TcOCl 4 ] with a slight stoichiometric excess of hydroxylamine hydrochloride in methanol followed by a crystallization from dichloromethane under ether to yield the analytically pure product. The recrystallization is critical when employing [Bu 4 N][Tc(NO)Cl 4 ] as a synthetic intermediate since residual hydroxylamine will can cause unintended redox chemistry in subsequent reactions.…”

Section: Introductionmentioning

confidence: 99%

The synthesis and X-ray structural characterization of mer and fac isomers of the technetium(I) nitrosyl complex [TcCl2(NO)(PNPpr)]

Nicholson

Mahmood

Refosco³

et al. 2009

Inorganica Chimica Acta

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The nitrosyl complex H[TcNOCl4] reacts with the tridentate ligand bis[(2-diphenylphosphino)propyl]amine (PNPpr) to yield a mixture of the mer or fac isomers of [TcCl2(NO)(PNPpr)]. In acetonitrile, where the ligand is freely soluble, reaction occurs at room temperature to yield mostly the mer isomer with the linear nitrosyl ligand cis to the amine ligand; and the phosphine ligands arranged in a mutually trans orientation. The reaction in methanol requires reflux to dissolve the lipophilic ligand and generates the fac isomer of [TcCl2(NO)(PNPpr)] as the major product, with the tridentate ligand in a facial arrangement, leaving the chlorides and nitrosyl ligand in the remaining facial sites. The steric bulk of the tridentate ligand's diphenylphophino- moieties results in a significant distortion from octahedral geometry, with the P-Tc-P bond angle expanded to 99.48(4)°. The infrared spectra display absorptions from these nitrosyl ligands in the 1700 and 1800 cm−1 regions for the fac and mer isomers respectively. The ESI(+) mass spectra each display the parent ion at 647 m/z.

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Thionitrosyl Complexes of Rhenium and Technetium with PPh3 and Chelating Ligands—Synthesis and Reactivity

Nowak,

Hagenbach,

Sawallisch

et al. 2024

Inorganics

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In contrast to corresponding nitrosyl compounds, thionitrosyl complexes of rhenium and technetium are rare. Synthetic access to the thionitrosyl core is possible by two main approaches: (i) the treatment of corresponding nitrido complexes with S2Cl2 and (ii) by reaction of halide complexes with trithiazyl chloride. The first synthetic route was applied for the synthesis of novel rhenium and technetium thionitrosyls with the metals in their oxidation states “+1” and “+2”. [MVNCl2(PPh3)2], [MVNCl(PPh3)(LOMe)] and [MVINCl2(LOMe)] (M = Re, Tc; {LOMe}− = (η5-cyclopentadienyl)tris(dimethyl phosphito-P)cobaltate(III)) complexes have been used as starting materials for the synthesis of [ReII(NS)Cl3(PPh3)2] (1), [ReII(NS)Cl3(PPh3)(OPPh3)] (2), [ReII(NS)Cl(PPh3)(LOMe)]+ (4a), [ReII(NS)Cl2(LOMe)] (5a), [TcII(NS)Cl(PPh3)(LOMe)]+ (4b) and [TcII(NS)Cl2(LOMe)] (5b). The triphenylphosphine complex 1 is partially suitable as a precursor for ongoing ligand exchange reactions and has been used for the synthesis of [ReI(NS)(PPh3)(Et2btu)2] (3a) (HEt2btu = N,N-diethyl-N′-benzoyl thiourea) containing two chelating benzoyl thioureato ligands. The novel compounds have been isolated in crystalline form and studied by X-ray diffraction and spectroscopic methods including IR, NMR and EPR spectroscopy and (where possible) mass spectrometry. A comparison of structurally related rhenium and technetium complexes allows for conclusions about similarities and differences in stability, reaction kinetics and redox behavior between these 4d and 5d transition metals.

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Synthesis and biological studies of the [99mTc]tetrachloronitrosyltechnetium(II) anion—An alternative low valent technetium starting material

Cited by 3 publications

References 6 publications

Nitrosyltechnetium(I) Complexes with 2‐(Diphenylphosphanyl)aniline

Nitrosyltechnetium(I) Complexes with 2‐(Diphenylphosphanyl)aniline

The synthesis and X-ray structural characterization of mer and fac isomers of the technetium(I) nitrosyl complex [TcCl2(NO)(PNPpr)]

Thionitrosyl Complexes of Rhenium and Technetium with PPh3 and Chelating Ligands—Synthesis and Reactivity

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