Synthesis and biological studies of silver N-heterocyclic carbene complexes derived from 4,5-diarylimidazole

Liu, Wukun; Bensdorf, Kerstin; Hagenbach, Adelheid; Abram, Ulrich; Niu, Ben; Mariappan, Aruljothi; Gust, Ronald

doi:10.1016/j.ejmech.2011.10.002

Cited by 60 publications

(60 citation statements)

References 31 publications

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“…Work-up 2: A modified work-up based on that of Liu and collarborators [20] was used. After the reaction, the methanol was evaporated and the residue dissolved in HCl (5%, 10 mL) and heated to about 80 8C.…”

Section: General Procedures For the Synthesis Of 45-bis-aryl-1h-imidamentioning

confidence: 99%

A Three‐Way Switchable Process for Suzuki Cross‐Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross‐Coupling Sequence

Sandtorv

Bjørsvik

2013

Adv Synth Catal

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A three-way switchable Pd-catalyzed and microwave assisted process appropriate for selective arylation or hydrodehalogenation of the imidazole backbone was discovered and entirely optimized. The "arylation switch position" was adapted and optimized for the synthesis of 4,5-diaryl-1H-imidazoles, while the "hydrodehalogenation switch position" was used for the preparation of 4(5)-iodo-1H-imidazole. The hydrodehalogenation and the cross-coupling reactions were also successfully combined in "the third switch position" that performs an assisted tandem reaction sequence that produced 4(5)-aryl-1H-imidazole. All of the three pathways produced their corresponding products in excellent yield.

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Section: General Procedures For the Synthesis Of 45-bis-aryl-1h-imidamentioning

confidence: 99%

A Three‐Way Switchable Process for Suzuki Cross‐Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross‐Coupling Sequence

Sandtorv

Bjørsvik

2013

Adv Synth Catal

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“…Additionally a larger number of known compounds were evaluated as potential antibiotics by Roland and Jolivalt [9]. Recently, Gust et al reported the anticancer activity of 4,5-diaryl-imidazole derived NHC silver complexes against MCF-7, MDA-MB-231 (breast) and HT-29 (colon) cancer cell lines [10].…”

Section: Introductionmentioning

confidence: 99%

Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes – Synthesis and biological evaluation

Hackenberg

Lally

Müller‐Bunz

et al. 2012

Journal of Organometallic Chemistry

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“…In addition, a silver complex with the antiinflammatory drug nimesulide (another sulfonamide) [13] was shown to be active against Gram-positive and Gram-negative bacteria. Moreover, the Ag(I) derivatives are currently being investigated as anticancer drugs [12,14].…”

Section: Introductionmentioning

confidence: 99%

Silver sulfadoxinate: Synthesis, structural and spectroscopic characterizations, and preliminary antibacterial assays in vitro

Zanvettor

Abbehausen

Lustri

et al. 2015

Journal of Molecular Structure

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Synthesis and biological studies of silver N-heterocyclic carbene complexes derived from 4,5-diarylimidazole

Cited by 60 publications

References 31 publications

A Three‐Way Switchable Process for Suzuki Cross‐Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross‐Coupling Sequence

A Three‐Way Switchable Process for Suzuki Cross‐Coupling, Hydrodehalogenation, or an Assisted Tandem Hydrodehalogenation and Suzuki Cross‐Coupling Sequence

Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes – Synthesis and biological evaluation

Silver sulfadoxinate: Synthesis, structural and spectroscopic characterizations, and preliminary antibacterial assays in vitro

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