Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines

Azam, MA; Kumar, Brp; Shalini, S.; Suresh, B.; Reddy, Tirumuru V.; Reddy, C. P.

doi:10.4103/0250-474x.45416

Cited by 22 publications

(9 citation statements)

References 17 publications

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“…Azam et al 8 have synthesized pyrimidine bridged thiadiazole derivatives 5-{(4,6-disubstituted pyrimidine-2-yl) thio methyl}-N-phenyl-1,3,4, thiadiazol-2-amines which exhibited significant antitumor activity against human breast cancer MCF 7 cell line. However, moderate antioxidant activity was observed.…”

Section: 3mentioning

confidence: 99%

The Antifungal Effect of some 4-Chloro-6-Methoxy-N, N-Dimethylpyrimidin-2-Amine Derivatives Containing a Heterocyclic Compound on the Important types of Fungi

Jafar¹,

Mahdi²,

Hadwan³

et al. 2017

JYP

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Objective: 4-methoxy-N, N-dimethyl-6-(phenylthio) pyrimidin-2-amine, 4-(benzo [d]thiazol-2-ylthio)-6-methoxy-N,N-dimethylpyrimidin-2-amine, 4-(4-(1,2,3-selenadiazol-4-yl)phenoxy)-6-methoxy-N,N-dimethylpyrimidin-2-amine and 4-(4-(1,2,3-thiadiazol-4-yl)phenoxy)-6-methoxy-N,N-dimethylpyrimidin-2-amine have been synthesized. Method: The prepared compounds were synthesized by nucleophilic displacement of chloride substituted in pyrimidine heterocyclic ring. Results: The synthesized compounds were being identified by different methods included TLC technique, IR, 1H-NMR and 13C-NMR spectrophotometers. All compounds confirmed by elemental analysis. The biological activity of these new compounds investigated against some fungi like Aspergillus terreus and Aspergillus niger, the results was Aspergillus terreus more effected by antifungal compare with Aspergillus niger, the effect ration 0.98, 1.32 with 200µM respectively and the compound number (2) has more effect than other compounds. Conclusion: It is concluded that synthesized dimethylpyrimidin-derivatives are biologically active and developed into useful Antifungal agents. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Section: 3mentioning

confidence: 99%

The Antifungal Effect of some 4-Chloro-6-Methoxy-N, N-Dimethylpyrimidin-2-Amine Derivatives Containing a Heterocyclic Compound on the Important types of Fungi

Jafar¹,

Mahdi²,

Hadwan³

et al. 2017

JYP

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“…Among the compounds, pyrimidine and pyridine-containing compounds, have been the subject of expanding research efforts in organic and biological chemistry. Interestingly, pyrimidine compounds are also known for possessing antitumor, anticancer and antineoplastic potencies 15,16 and are very essential for synthetic drugs (e.g., barbituric acid derivatives), chemotherapeutic agents (e.g., sulfadiazine), and agricultural chemicals 17 . The formation of carbon-nitrogen bonds are the most important transformations in organic chemistry [18][19][20][21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Schiff Base Substituted Carbazole Bearing Pyridopyrimidine Compounds

Rifati-Nixha¹,

Arslan²

2018

RJC

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The Schiff bases formation which is useful molecules both biologically and synthetically is one of the most important reactions in organic and medicinal chemistry. Available materials, catalyst-free and mild reaction conditions are essential to synthesize the Schiff bases in a good yield. In basic conditions, Schiff base substituted carbazole bearing pyridopyrimidine compounds (4a-n) were efficiently synthesized through corresponding benzaldehyde derivatives on treatment with 7-(4-amino-phenyl)-5-(9-ethyl-9H-carbazol-3-yl)-1,3-dimethyl-1Hpyrido [2,3-d] pyrimidine-2,4-dione in tetrahydrofuran under reflux in good yields. The structures of the synthesized compounds were identified by IR, 1 H NMR and 13 C NMR and elemental analysis.

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“…They are reported to possess broad spectrum of biological activities as well 20,21 . In pursuit of this goal, it was proposed to carry out the synthesis and biological screening of aforesaid heterocycles with appropriate substitution, with improved efficacy and decreased toxicity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vivo diuretic activity of some novel pyrimidine derivatives

Majeed

Shaharyar

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines

Cited by 22 publications

References 17 publications

The Antifungal Effect of some 4-Chloro-6-Methoxy-N, N-Dimethylpyrimidin-2-Amine Derivatives Containing a Heterocyclic Compound on the Important types of Fungi

The Antifungal Effect of some 4-Chloro-6-Methoxy-N, N-Dimethylpyrimidin-2-Amine Derivatives Containing a Heterocyclic Compound on the Important types of Fungi

Synthesis and Characterization of Schiff Base Substituted Carbazole Bearing Pyridopyrimidine Compounds

Synthesis and in vivo diuretic activity of some novel pyrimidine derivatives

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