Synthesis and biological properties of some dibenzazepines and dibenzazonines related to protostephanine

Direct construction of biaryl-bridged 8–11 membered N-heterocycles via gold(i)-catalyzed intramolecular [4 + 2] benzannulation of N-tethered diynyl benzaldehydes

“…1). 2–8 For instance, buflavine, apogalanthamine, and aza-isopicrostegane, all feature a structurally constrained biaryl-bridged azocine skeleton, showing a broad spectrum of biological activities, such as α-adrenolytic, anti-serotonin, and anti-cancer activities. 2–4 Protostephanine, possessing a 6,7,8,9-tetrahydrodibenzo[ d , f ]azonine skeleton, has been found to have an interesting hypotensive effect.…”

“…2–4 Protostephanine, possessing a 6,7,8,9-tetrahydrodibenzo[ d , f ]azonine skeleton, has been found to have an interesting hypotensive effect. 5 (−)-Rhazinilam is a prospective antitubulin agent. 6 Dysazecine, featuring a rare 5,6,7,8,9,10-hexahydrodibenzo[ d , f ]azecine structure and isolated from Dysoxylum lenticellare Gillespie, displays promising molluscicidal activity.…”