Synthesis and biological properties of N-(ω-aminoalkyl)-substituted 2-pyrrolidones and their derivatives

N-[Morpholino(phenyl)methyl]benzamide

“…For background literature on benzamides and morpholines, see: Carbonnelle et al (2005); Hatzelmann & Schudt (2001); Li et al (1998); Malik et al (2006); Sedavkina et al (1984); Simonini et al (2006); Suzuki et al (2005); Zhou et al (1999); Zhou et al (1999). For ring conformations, see: Cremer & Pople (1975).…”

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

“…To collect additional information and to measure the impact of these variation points on the N-arylation step, five types of substrates (I-V) were designed and investigated. Significantly, scaffolds bearing various groups having different electron-withdrawing or electron-donating properties such as ester (2a,b;Type I), amide (2c-h; Type II), ether (3a), amine (3b,c) or retroamide (3d) belonging to the family of Type III, aryl (4, 5; Type IV), and finally some lactam vinylogues (6-10; Type V) were chosen and investigated (Scheme 1).…”