Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX

Synthesis, characterization and biological evaluation of pyrazole-based benzene sulfonamides as inhibitors of human carbonic anhydrase II, IX and XII

“…The inhibitory activity of synthesized compounds against carbonic anhydrases was determined spectrophotometrically, as previously described. 14 The activity assay was performed in tris-base buffer containing 50 mM tris-base and 0.1 mM of ZnCl 2 . The pH was adjusted to 7.4.…”