Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives

Abstract

Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields. Their structures were characterized by 1 HNMR. Three target compounds (4a~4c) have not been reported before. The results showed that: pre-treated of PC-12 cells with, cell survival rate was higher than that of quercetin. In this project, the oxidative damage model of PC-12 cells was established and the antioxidant activities of three newly synthesized quercetin derivatives were evaluated. Among them, compound 4b (30μM) showed the highest antioxidant activity against H 2 O 2. Cell viability in pre-treated with or without compound 4b (30μM) were 53.05% and 10.31%, higher than that of quercetin (47.22%).