2008
DOI: 10.1016/j.ejmech.2007.11.029
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Synthesis and biological evaluation of pyrazoline analogues with β-amino acyl group as dipeptidyl peptidase IV inhibitors

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Cited by 30 publications
(3 citation statements)
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“…29 Many inhibitors of DPP-4 (Figure 1) possess five-membered heterocyclic rings (e.g., pyrrolidine, thiazolidine) as proline mimics at the P1 position. 30 Vildagliptin (2), saxagliptin (3), anagliptin (4), gosogliptin (5), and teneligliptin (6) (Figure 2) are approved DPP-4 inhibitors with pyrrolidine or analogs as P1 fragment with an α-aminoacyl linker. 31−33 P1 Fragment.…”
Section: ■ Dpp-4 Inhibitors With Pyrrolidine or Analogs As P1 Fragmen...mentioning
confidence: 99%
See 1 more Smart Citation
“…29 Many inhibitors of DPP-4 (Figure 1) possess five-membered heterocyclic rings (e.g., pyrrolidine, thiazolidine) as proline mimics at the P1 position. 30 Vildagliptin (2), saxagliptin (3), anagliptin (4), gosogliptin (5), and teneligliptin (6) (Figure 2) are approved DPP-4 inhibitors with pyrrolidine or analogs as P1 fragment with an α-aminoacyl linker. 31−33 P1 Fragment.…”
Section: ■ Dpp-4 Inhibitors With Pyrrolidine or Analogs As P1 Fragmen...mentioning
confidence: 99%
“…The S1 domain is considered a decisive site for binding of DPP-4 inhibitors . Many inhibitors of DPP-4 (Figure ) possess five-membered heterocyclic rings (e.g., pyrrolidine, thiazolidine) as proline mimics at the P1 position …”
Section: Dpp-4 Inhibitors With Pyrrolidine or Analogs As P1 Fragment ...mentioning
confidence: 99%
“…They have been found to possess antimicrobial, antidiabetic, antidepressant, anticancer, hypotensive, antiamoebic, anti-inflammatory and antitubercular activity [2][3][4][5][6][7][8][9][10]. As a part of our research programme on pyrazoline derivatives [11], we report herein the synthesis of [5-(1,3-diphenyl-1H-pyrazol-4-yl)-3-phenyl-4,5-dihydropyrazol-1-yl](pyridin-4-yl)methanone (2).…”
Section: Introductionmentioning
confidence: 98%