Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory–antimicrobial agents

Crystal structure of N′-(4-methoxybenzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide, C18H16N4O2

“…Pyrazole are an important class of heterocyclic compounds and many pyrazole derivatives are reported to have a broad spectrum of biological properties, including antiin ammatory and antimicrobial activities [1], anticancer [2], antidepressant [3], anticonvulsant [4] and antiviral properties [5]. Because of these various interesting elds of application as well as their fairly assessable path of synthesis, the pyrazole ring became a center of attraction for organic chemist.…”

POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues

“…[1][2][3][4][5][6][7][8] Earlier we have reported the antitubercular and anticonvulsant activities of some novel pyrazoline derivatives. [9][10][11][12] The present letter is the continuation of the previous work and we have focused here on the bioinformatics of the synthesized compounds with the help of computational method viz.…”

Synthesis and Antibacterial Screening of Novel Fluorine Containing Heterocycles

“…Chalcones are open chain flavonoids widely distributed in plants and are known to possess diverse biological properties like antimicrobial 13 , antitubercular 14,15 , antioxidant 15 and antitumor 16 . More recently pyrazolyl chalcones have been studied for antioxidant 17 , antimicrobial 17,18 , DNA gyrase inhibitor 18,19 , antitumor 20 and antiinflammatory 21,22 properties.…”