Synthesis and biological evaluation of cholic acid-conjugated oxaliplatin as a new prodrug for liver cancer

Jiang, Jing; Han, Fuguo; Cai, Kaixuan; Shen, Qingwu; Yang, Chen; Gao, Anli; Yu, Juan; Fan, Xing; Hao, Yanli; Wang, Zhao; Liu, Weiping; Shi, Yun Q.; Liu, Qingfei

doi:10.1016/j.jinorgbio.2023.112200

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…Adjusted age, gender, race, educational levels, BMI, family income-poverty ratio level, married status, smoking status, drinking status, diabetes and hypertension. mental health has a significant impact, further research on the mechanisms and preventive measures is warranted (12,14,42). The findings of this study have important clinical and epidemiological significance.…”

Section: Discussionmentioning

confidence: 79%

“…Chronic inflammation caused by beryllium is considered a possible contributor to the carcinogenicity of beryllium to humans ( 24 , 48 ). Currently, there is no research analyzing the synergistic effects of Cd and depression on PSA, and in an era where mental health has a significant impact, further research on the mechanisms and preventive measures is warranted ( 12 , 14 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

“…After ingestion through food, water, and air, the human body metabolizes and eliminates heavy metals in various ways, primarily through urine. The concentration of heavy metals in urine provides an indication of the body's metal levels after metabolism (14,15). The International Association for Research on Cancer (IARC) has classified beryllium and beryllium-containing compounds as Group 1 carcinogens.…”

Section: Introductionmentioning

confidence: 99%

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Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Ren,

Zhang,

2024

Front. Public Health

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ObjectiveThis study aims to investigate the impact of depression and urinary metals on Prostate-Specific Antigen (PSA).MethodsAnalysis was conducted on 1901 samples collected from the National Health and Nutrition Examination Survey (NHANES) database between 2001 and 2010. Analytical methods included stepwise multiple linear regression (MLR) analysis of the overall population’s urinary metals and PSA relationship, analysis of urinary metals and PSA relationship in older adults and BMI subgroups, analysis of urinary metals and PSA relationship in the depressed population, and restricted cubic spline (RCS) analysis. A significance level of p < 0.05 was considered statistically significant.ResultsIn the stepwise multiple linear regression, beryllium (Be) showed a dose–response association with PSA (third quartile: β = 0.05, 95%CI (0.02, 0.09); fourth quartile: β = 0.07, 95%CI (0.02, 0.12), p trend = 0.048). Subgroup analysis indicated that in individuals aged >60, Be at Q4 level [β = 0.09, 95%CI (0.05, 0.21)] exhibited a dose–response correlation with PSA. In the population with 25 ≤ BMI < 30, Be might more significantly elevate PSA, with Q4 level having a pronounced impact on PSA levels [β = 0.03, 95%CI (0.02, 1.27)]. In the depressed population, urinary cadmium (Cd) levels showed a significant positive dose–response relationship, with Q4 level of Cd having the maximum impact on PSA [β = 0.3, 95%CI (0.09, 0.49)].ConclusionIndividuals exposed to beryllium (Be), especially the older adults and overweight, should monitor their PSA levels. In depressed patients, cadmium (Cd) levels may further elevate PSA levels, necessitating increased monitoring of PSA levels among males.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Ren,

Zhang,

2024

Front. Public Health

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“…LLC-202 possessed higher anticancer activity and efficacy than oxaliplatin through the induction of apoptosis. These findings highlighted the promising potential of LLC-202 as a liver cancer-specific prodrug ( Jiang et al, 2023 ).…”

Section: Synthetic Ba Derivatives Against Cancermentioning

confidence: 86%

The anticancer activity of bile acids in drug discovery and development

Li,

Zou,

Huang

et al. 2024

Front. Pharmacol.

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Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system. They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. In additional, BAs have demonstrated the ability to attenuate disease progression such as diabetes, metabolic disorders, heart disease, and respiratory ailments. Intriguingly, recent research has offered exciting evidence to unveil their potential antitumor properties against various cancer cell types including tamoxifen-resistant breast cancer, oral squamous cell carcinoma, cholangiocarcinoma, gastric cancer, colon cancer, hepatocellular carcinoma, prostate cancer, gallbladder cancer, neuroblastoma, and others. Up to date, multiple laboratories have synthesized novel BA derivatives to develop potential drug candidates. These derivatives have exhibited the capacity to induce cell death in individual cancer cell types and display promising anti-tumor activities. This review extensively elucidates the anticancer activity of natural BAs and synthetic derivatives in cancer cells, their associated signaling pathways, and therapeutic strategies. Understanding of BAs and their derivatives activities and action mechanisms will evidently assist anticancer drug discovery and devise novel treatment.

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“…The main clinical particularities of this cancer involve white stools, hepatitis B, hepatitis C, jaundice, considerable weight loss, vomiting, and abdominal pain (Mehmood et al, 2022). Nonetheless, symptoms are insidious at early disease stages, and most patients are diagnosed only when cancer reaches advanced levels (Jiang et al, 2023). Overall, given the elevated number of liver cancer-related deaths, incidence, and severity, chemo-gene combinatorial therapies have been devised to provide an alternative treatment against hepatic cancer (Wang et al, 2021c).…”

Section: Liver Cancermentioning

confidence: 99%

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Bravo-Vázquez,

Méndez-García,

Rodríguez

et al. 2023

Front. Bioeng. Biotechnol.

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MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules responsible for regulating gene expression via sequence-specific post-transcriptional mechanisms. Since the human miRNA transcriptome regulates the expression of a number of tumor suppressors and oncogenes, its dysregulation is associated with the clinical onset of different types of cancer. Despite the fact that numerous therapeutic approaches have been designed in recent years to treat cancer, the complexity of the disease manifested by each patient has prevented the development of a highly effective disease management strategy. However, over the past decade, artificial miRNAs (i.e., anti-miRNAs and miRNA mimics) have shown promising results against various cancer types; nevertheless, their targeted delivery could be challenging. Notably, numerous reports have shown that nanotechnology-based delivery of miRNAs can greatly contribute to hindering cancer initiation and development processes, representing an innovative disease-modifying strategy against cancer. Hence, in this review, we evaluate recently developed nanotechnology-based miRNA drug delivery systems for cancer therapeutics and discuss the potential challenges and future directions, such as the promising use of plant-made nanoparticles, phytochemical-mediated modulation of miRNAs, and nanozymes.

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Synthesis and biological evaluation of cholic acid-conjugated oxaliplatin as a new prodrug for liver cancer

Cited by 6 publications

References 47 publications

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

The anticancer activity of bile acids in drug discovery and development

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

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