Synthesis and Biological Evaluation of Amide Derivatives of Thiazoles as Anticancer Agents

Pinninti, Sateesh Kumar; Parimi, Umadevi

doi:10.7897/2230-8407.0910232

Int. Res. J. Pharm.

2018

DOI: 10.7897/2230-8407.0910232

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Synthesis and Biological Evaluation of Amide Derivatives of Thiazoles as Anticancer Agents

Sateesh Kumar Pinninti¹,

Umadevi Parimi²

Abstract: In this study, a series of amide derivatives (11a-j) containing thiazole moiety were designed and synthesized. All these synthesized compounds were confirmed by 1HNMR, 13CNMR and mass spectral data. Further, these were evaluated for anticancer activity against three human cancer cell lines including MCF-7 (breast), A-549 (lung), and A375 (melanoma). Among them, compounds 11b, 11d, 11e, 11f and 11g were exhibited more potent activity than positive control.

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2020

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Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity

Yan¹,

Wen

Zhou³

et al. 2020

CTMC

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: Cancer which has been cursed for human beings for long time is considered as one of the leading causes of morbidity and mortality across the world. In spite of different types of treatments available, chemotherapy is still deemed as a favored treatment for the cancer. Unfortunately, many currently accessible anticancer agents have developed multidrug resistance along with fatal adverse effects. Therefore, intensive efforts have been made to seek for new active drugs with improved anticancer efficacy and reduced adverse effects. In recent years, the emergence of heterocyclic ring-containing anticancer agents has gained a great deal of attention among medicinal chemists. 1,3-Oxazole is a versatile heterocyclic compound, and its derivatives possess broad-spectrum pharmacological properties including anticancer activity against both drug-susceptible, drug-resistant and even multidrug-resistant cancer cell lines through multiple mechanisms. Thus, the 1,3- oxazole moiety is a useful template for the development of novel anticancer agents. This review will provide a comprehensive overview of the recent advances on 1,3-oxazole derivatives with potential therapeutic applications as anticancer agents, focus on the chemical structures, anticancer activity, and mechanisms of action.

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Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity

Yan¹,

Wen

Zhou³

et al. 2020

CTMC

View full text Add to dashboard Cite

show abstract

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Synthesis and Biological Evaluation of Amide Derivatives of Thiazoles as Anticancer Agents

Cited by 1 publication

References 16 publications

Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity

Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity

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