Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach

Kategaonkar, Amol H.; Shinde, Pravin V.; Kategaonkar, Atul H.; Pasale, Sharad K.; Shingate, Bapurao B.; Shingare, Murlidhar S.

doi:10.1016/j.ejmech.2010.04.002

Cited by 99 publications

(43 citation statements)

References 26 publications

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“…Kategaonkar and co-workers reported antimicrobial activities of new 2-chloro-3-[(4-phenyl-1 H-1,2,3-triazol-1-yl)-methyl]quinoline derivatives (44) against a large number of fungal and bacterial strains. [108] Leishmaniasis is caused by several species of protozoan parasites transmitted by the bite of the female phlebotomine sand fly. Classified as an extremely neglected disease, leishmaniasis is still present as an additional difficulty in the long and inefficient treatment that is dependent on old and highly toxic drugs like azole antifungals.…”

Section: Antifungal and Antibacterialsmentioning

confidence: 99%

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

Agalave

Maujan

Pore

2011

Chemistry An Asian Journal

1,143

508

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The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

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Section: Antifungal and Antibacterialsmentioning

confidence: 99%

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

Agalave

Maujan

Pore

2011

Chemistry An Asian Journal

1,143

508

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“…[11][12][13][14][15] These compounds can act as rigid linking units and can mimic the atom placement and electronic properties of a peptide bond, but with no hydrolytic cleavage effect. It is important to note that 1,2,3-triazoles have the following structural and electronic features, which have a signicant high impact on their biological pharmaceutical applications.…”

Section: -10mentioning

confidence: 99%

Computational investigations of click-derived 1,2,3-triazoles as keystone ligands for complexation with transition metals: a review

2018

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In recent years, metal complexes of organo 1,2,3-triazole click-derived ligands have attracted significant attention as catalysts in many chemical transformations and also as biological and pharmaceutical active agents. Regarding the important applications of these metal-organo 1,2,3-triazole-based complexes, in this review, we focused on the recently reported investigations of the structural, electronic, and spectroscopic aspects of the complexation process in transition metal complexes of 1,2,3-triazole-based click ligands. In line with this, the coordination properties of these triazole-based click ligands with transition metals were studied via several quantum chemistry calculations. Moreover, considering the complexation process, we have presented comparative discussions between the computational results and the available experimental data.

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“…They have taken a leading position in the medicinal chemistry and are also being used as important pharmacophores in the field of drug design. In additon, triazole is a unique template that is associated with a number of biological activities and this moiety is an attractive option to use it as a structural component in the design of new molecules as it is stable in acidic/basic conditions [19], also has a high dipole moment and affords the possibility of forming hydrogen bonds with bimolecular targets [20]. …”

Section: Introductionmentioning

confidence: 99%