Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives

Dimroth-type N/S-interchange of N-aminothioglycolurils in the synthesis of 2-hydrazonoimidazo[4,5-d]thiazolones

“…At first, N -aminothioglycoluril derivatives 8a–o were prepared according to earlier developed procedure starting from 3-thioxoperhydroimidazo[4,5- e ]-1,2,4-triazines 9a–c and aromatic aldehydes or 3-phenylacrylaldehyde derivatives ( Scheme 2 ). 11 The yields of thioglycolurils 8a–j, l–o were close to described values. 11 New compound 8k was synthesized in 35% yield.…”

“… 11 The yields of thioglycolurils 8a–j, l–o were close to described values. 11 New compound 8k was synthesized in 35% yield. Introduction of phenyl substituent at the N(5) atom of starting compound 9c led to the significant decrease of the reaction product yield compared to the yields of 8a,f.…”

“…Recently, 11 we have developed an approach to preparation of thioglycolurils 8 based on the tandem hydrazone formation and triazine ring contraction reaction of 3-thioxoperhydroimidazo[4,5- e ]-1,2,4-triazin-6-ones 9 with aromatic aldehydes or 3-phenylacrylaldehyde derivatives.…”

Synthesis, activity evaluation, and pro-apoptotic properties of novel 1,2,4-triazol-3-amine derivatives as potent anti-lung cancer agents

“…Triazole and its derivatives have a broad range of biological and pharmacological properties, such as anti-bacterial, anti-human immunodeficiency virus 2 , anti-microbial 3 , anti-fungal 4 , anti-viral 5 , and anti-cancer effects 6–14 . For example, Abdou et al .…”

Synthesis and Structure of 1-Substituted Semithioglycolurils

“…2,6 More and more research has focused on semithioglycolurils I-IX (Figure 1), 2, including compounds I, II, V, VII, and VIII that were synthesized in our laboratory. 6,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Although a wide range of trisubstituted semithioglycolurils I and II have been reported, they are still actively investigated, as some of them have antifungal and cytotoxic activities. 12,13 Other compounds III-IX are represented by several examples and used as scaffolds in the synthesis of semithiobambusurils (III and VII), 11,27 in Claisen condensation matrices (IV), 10 and in the synthesis of tri-, tetra-, and polycyclic systems (V) [28][29][30][31] and iminoglycolurils (V, VII, VIII).…”