Synthesis and Biological Evaluation of Novel Zn(II) and Cd(II) Schiff Base Complexes as Antimicrobial, Antifungal, and Antioxidant Agents

Abstract

(E)-N,N-Dimethyl-2-((E-1-(2-(p-tolyl)hydrazono)propan-2-ylidene)hydrazine-1-carbothioamide (DMPTHP) and their Zn(II) and Cd(II) complexes have been synthesized and characterized. Different tools of analysis such as elemental analyses, IR, mass spectra, and 1H-NMR measurements were used to elucidate the structure of the synthesized compounds. According to these spectral results, the DMPTHP ligand behaved as a mononegatively charged tridentate anion. Modeling and docking studies were investigated and discussed. Novel Schiff base (DMPTHP) ligand protonation constants and their formation constants with Cd(II) and Zn(II) ions were measured in 50% DMSO solution at 15°C, 25°C, and 35°C at I = 0.1 mol·dm−3 NaNO3. The solution speciation of different species was measured in accordance with pH. Calculation and discussion of the thermodynamic parameters were achieved. Both log K1 and –ΔH1, for M(II)-thiosemicarbazone complexes were found to be somewhat larger than log K2 and –ΔH2, demonstrating a shift in the dentate character of DMPTHP from tridentate in 1 : 1 chelates to bidentate in 1 : 2; M : L chelates and steric hindrance were generated by addition of the 2nd molecule. The compounds prepared have significant activity as antioxidants, similar to ascorbic acid. It is hoped that the results will be beneficial to antimicrobial agent chemistry. The formed compounds acted as a potent antibacterial agent. Molecular docking studies were investigated and have proved that DMPTHP as antibacterial agents act on highly resistant strains of E. coli and also as an anticancer agent.

Phytochemical Profiling, and Antioxidant Potentials of South African and Nigerian Loranthus micranthus Linn.: The African Mistletoe Exposé

“…leaves are composed of flavonoids, tannins, saponins, terpenoids, and cardiac glycosides, according to a qualitative study conducted previously [ 28 ]. In the current study, there was no positive test for alkaloids for both the Nigerian and South African mistletoe tree extracts, which contradicts many studies conducted before this one [ 13 , 25 ]. This observation may partly be a result of the alkaloids being possibly below the limit of detection for the analysed extracts.…”

“…Changes in color, from purple to yellow, indicate a decrease in absorbance of a DPPH radical. This demonstrates that the antioxidant agents found in a plant extract mixture interact with the hydrogen radicals [ 25 ]. The results for the NGDCM extract are displayed in Figure 1 A.…”

Study of novel bidentate heterocyclic amine-based metal complexes and their biological activities: cytotoxicity and antimicrobial activity evaluation

“…A triforce XMTD-3000 was used to evaluate the melting point. The electron ionization technique at 70 eV with an MS-5988 GS-MS Hewlett-Packard apparatus was used to record the mass spectra of the prepared complexes [ 63 ]. The various chelates' IR spectra in the KBr disc in the 4000–400 cm −1 range were evaluated on a PerkinElmer 1650 spectrometer to assess the different ligands-metal ions' binding modes in the chelates and compared to the free ligands [ 64 ].…”

Zinc(II)‐facilitated nucleophilic addition on N‐(4‐chlorophenyl) carbon hydrazonoyl dicyanide and hybrid complex formation: X‐ray, spectral characteristics, DFT, molecular docking, and biological studies

“…[24] Many studies via theoretical calculations have been performed to investigate and improve the performance of different materials in many applications. [25,26] Theoretical applications as molecular docking can be extremely valuable in the pharmaceutical field to predict the efficiency of a structurally known substance as a medicine. [27,28] In this work, we are targeting to (i) synthesize of N-chlorophenyl carbonohydrazonoyl dicyanide, NCCD, (ii) study the reaction of the synthesized NCCD compound with zinc acetate dihydrate, (iii) characterize the synthesized products, utilizing elemental analyses FTIR, NMR ( 1 H, 13 C), XPS, UV/Vis, and single-crystal X-ray molecular structure, (iv) compare experimental data with the DFT calculations of the products and study their molecular docking, and (v) study the in vitro antibacterial, antifungal, anticancer, and cytotoxicity of the synthesized compounds.…”