Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Crystal structure of 1-(2H-1,3-benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propan-1-one, C13H12N2O3

“…Their current importance is testified by their ubiquitousness in the fields of medicinal chemistry, material science and agrochemicals [1]. Imidazole-based compounds exhibit diverse biological activities anticancer [2][3][4][5] antibacterial [6,7], antitubercular [8,9], antifungal [10,11], antiviral [12][13][14], anticonvulsant [15][16][17] and antiparkinson's agents [18,19]. The [20][21][22].…”

Imidazole and its derivatives as potential candidates for drug development

“…The most significant activity was observed by compound 4 (EC50 = 0.18 LM) with electron withdrawing nitro group, and compound 5 (EC50 = 0.20 LM) with electron donating group at meta positions of the compounds. These two compounds were found more active as compared to the reference drugs nevirapine and delavirdine (Zhan et al, 2009). …”

Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components

“…They have been used, for example, in metallo-ligand self-assembly to generate discrete supramolecular assemblies such as metallosupramolecular helicates, [28][29][30] cages [31], and capsules, [32] and have also been used with a variety of transition metals in catalysis [33,34]. In addition, Schiff base derivatives showed a variety of biological and pharmacological activities as antimicrobial, [35] antidepressant, [36] cytotoxic, [37] analgesic, [38] anti-HIV, [39] antileishmanial, [40] anticonvulsant, [41] fungicides, [42] anti-inflammatory [43], and anticancer [44]. In this present investigation work, we are interested by the combination of the azo group, the imidazole unit and the Schiff base fragment.…”