Synthesis and biological evaluation of arene ruthenium(II) complexes containing thiophene benzhydrazone derivative ligands

TfOH-promoted multichannel transformations of trifluoromethyl side chain substituted thiophene and furan families to access antimicrobial agents

“…Since the thiophene ring is an essential part of the widely used antibiotics Cefoxitin and Temocillin, as well as antifungal agents such as Sertaconazole and Tioconazole (Fig. 1), a significant body of current research is devoted to the synthesis and investigation of antimicrobial activity of some novel thiophene derivatives, 2–9 including recently isolated natural compounds, 10 as well as thiophene-containing metal–organic complexes, 11,12 oligomeric 13,14 and polymeric materials. 15…”