“…). 30 In the present study, the lipophilicity of the selected derivatives 5a , 5c , 10f , and 13o was improved as compared with that of the parent molecule (Table S6†).…”
Section: Resultsmentioning
confidence: 54%
“…of the drug could cause the level of drug administration in animal model (intestinal, blood brain barrier etc.). 30 In the present study, the lipophilicity of the selected derivatives 5a, 5c, 10f, and 13o was improved as compared with that of the parent molecule (Table S6 †).…”
Novel piperazine-linked bergenin derivatives were synthesized and the compounds 5a, 5c, 10f, and 13o showed excellent cytotoxic activity. These compounds arrest the cell cycle and induce apoptosis by regulating the Bax/BcL2 expression.
“…). 30 In the present study, the lipophilicity of the selected derivatives 5a , 5c , 10f , and 13o was improved as compared with that of the parent molecule (Table S6†).…”
Section: Resultsmentioning
confidence: 54%
“…of the drug could cause the level of drug administration in animal model (intestinal, blood brain barrier etc.). 30 In the present study, the lipophilicity of the selected derivatives 5a, 5c, 10f, and 13o was improved as compared with that of the parent molecule (Table S6 †).…”
Novel piperazine-linked bergenin derivatives were synthesized and the compounds 5a, 5c, 10f, and 13o showed excellent cytotoxic activity. These compounds arrest the cell cycle and induce apoptosis by regulating the Bax/BcL2 expression.
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