Synthesis and biological evaluation of novel bi-gold mitocans in lung cancer cells
Wenwen Ding,
Qingbin Cui,
Wenhua Lu
et al.
Abstract:Mitochondria are promising drug target for cancer treatment. We previously demonstrated that a bi-gold compound BGC2a was more potent than the mono-gold drug auranofin in suppressing cancer cells due to increased gold atom number that led to higher drug accumulation in and thereby inhibition of mitochondria. To exploit the potential of this new strategy, we further designed and synthesized a series of bi-gold mitocans, the compounds targeting mitochondria. The results showed that most of the newly synthesized … Show more
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