Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents

Design, synthesis, characterization, quantum-chemical calculations and anti-inflammatory activity of novel series of thiophene derivatives

“…They are reported to exert a number of important physiological activities such as antidiabetic [11], antihyperlipo-proteinemics [12], antiemetic [13], platelet aggregation inhibitors, bronchodilators and growth stimulates [14] and anti-inflammatory [15]. These were also used in treatment of inflammatory diseases, pain, migraine and asthma [16].…”

“…The applicability of the semiempirical methods PM3 for the calculation of novel synthesized compounds has been evaluated [19]. In a continuance of our research program directed towards synthesis of medicinally potent new chemical entities and their biological screening, the present study is aimed to study synthesis, characterization, molecular modeling and biological evaluation of various novel bioactive compounds heterocyclic compounds [20][21][22][23][24][25]. It seems therefore to be of considerable interest to synthesize newly heterocyclic compounds containing both the thiophene and morpholine moieties.…”

Synthesis, biological evaluation and molecular modeling of novel series of pyridine derivatives as anticancer, anti-inflammatory and analgesic agents

“…In continuation of our research program [18][19][20][21][22][23][24][25][26][27][28] focused on synthesis of medicinally potent new chemical entities and their biological screening, the present study is aimed to study synthesis, characterization, molecular modeling and (SAR) and biological evaluation of various pyridones.…”

Solvent-free synthesis of novel (E)-2-(3,5-dimethyl-4-(aryldiazenyl)-1H-pyrazol-1-yl)-4-arylthiazoles: determination of their biological activity

“…Among them, thiazoles, pyrazoles and thiazole-pyrazole hybrids have attracted great attention over the years due to their remarkable biological activities. In this context, the motifs containing thiazole nucleus exhibited antitrypanosomal (Zelisko et al, 2012), antimicrobial (Desai et al, 2013), anticancer (Romagnoli et al, 2012), anti-inflammatory (Helal et al, 2013) and antiviral (Barradas et al, 2011) properties. Some potent drugs like fanetizole (anti-inflammatory agent), tiazofurin (antineoplastic agent), penicillin (potent antibiotic), sulfatiazol (antimicrobial) and abafungin (antifungal) also possessed thiazole ring (Karthikeyan, 2010;Bondock et al, 2013;Karuvalam et al, 2012).…”