Synthesis and Biological Evaluation of Some New Pyrimidine Derivatives

Abstract

New pyrimidine derivatives comprising azo, schiff's bases, chalcones, and chromene ring moieties were prepared.The newly synthesized compounds have been established on the basis of their m.p., TLC, FT-IR, UV-Vis ,¹H-NMR data and element analysis. These compounds were screened for their antimicrobial and in vitro antioxidant properties. The results of this investigation revealed that these compounds are potent antimicrobial and antioxidant agent.

Synthesis, Characterization, and Antimicrobial Evaluation of the Novel Triazolotriazolopyridines and Pyridotriazolotriazines

“…In our previous work , some novel polyfused heterocyclic systems, namely, pyrido[1′,2′:2,3][1,2,4]triazolo[1,5‐ c ]quinazolines and thiazolo[3′,2′:2,3][1,2,4]triazolo[1,5‐ a ] pyridines, have been synthesized. The present work aimed to utilize 1,6‐diamino‐4‐(4‐methoxyphenyl)‐2‐oxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile ( 1 ) to synthesize a novel series of polyfused nitrogen heterocyclic compounds, namely, [1,2,4]triazolo[4′,3′:2,3][1,2,4]triazolo[1,5‐ a ]pyridines and pyrido[1′,2′:2,3][1,2,4]triazolo[5,1‐ c ][1,2,4]triazines.…”

“…4‐Aryl‐1,6‐diamino‐2‐oxo‐1,2‐dihydropyridine‐3,5‐dicarbonitriles have been used for the synthesis of biologically active nitrogen bridgehead triazolo[1,5‐ a ]pyridines , pyrido[1,2‐ b ][1,2,4]triazines , and pyrido[1,2‐ b ][1,2,4]triazepines . As a part of our previously mentioned work directed for the synthesis of new polynuclear bioactive heterocyclic systems , the present work aimed to synthesize and utilize the novel 2‐hydrazinyl‐7‐(4‐methoxyphenyl)‐5‐oxo‐3,5‐dihydro[1,2,4]triazolo[1,5‐ a ]pyridine‐6,8‐dicarbonitrile ( 5 ) as a precursor to synthesize a novel series of polyfused heterocyclic systems including [1,2,4]triazolo[4′,3′:2,3][1,2,4]triazolo[1,5‐ a ]pyridines and pyrido[1′,2′:2,3][1,2,4]triazolo[5,1‐ c ][1,2,4]triazines and evaluate their antimicrobial activity.…”