Synthesis and Biological Evaluation of Novel Tricyclic Pyrrolidinyl (R)‐Alcohols and Amines

Abstract

Three new tricyclic pyrrolidinyl alcohols and three tricyclic pyrrolidinyl amines were synthesized, and the antibacterial activities of these compounds were tested against Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli O157:H7, Staphylococcus aureus, and Listeria monocytogenes. All tested pyrrolidinyl alcohols and amines showed antibacterial activity to the tested pathogens, but this activity was dependent on the final concentration of the tested compound, and the structure of these compounds were also important for this antibacterial activity. Of the tested compounds, (2R)‐2‐(octahydro‐4,8‐ethanocyclohepta[c]pyrrol‐2(1H)‐yl)‐2‐phenylethanamine (2c) was the most effective compound among the tested pyrrolidinyl alcohols and amines. This study shows a good example of finding new antimicrobials in order to control pathogenic bacteria.

Chemical States of Plasma Polypyrrole Coatings on Stainless Steel Stents

“…Materials as metal, paper or fabric have been covered with Polypyrrole (PPy) to be used in biomedical applications, sensing devices, conducting fabrics and papers, among others. [6][7][8][9][10] Plasma polypyrroles doped with iodine have shown affinity to solutions of salt concentration similar to human tissues with high possibilities to interact with cell tissues. [11] Nitinol and SS substrates covered with PPy have been immersed for 24 h in phosphate buffered solutions (PBS) with pH similar to blood observing that the coatings on nitinol were bonded stronger than on SS.…”