Synthesis and biological evaluation of novel salicylidene uracils: Cytotoxic activity on human cancer cell lines and inhibitory action on enzymatic activity
Ayşe Halıç Poslu,
Şafak Esra Aslan,
Gamze Koz
et al.
Abstract:A series of salicylidene uracil (1–18) derived from 5‐aminouracil and substituted salicylaldehydes were analyzed for cytotoxic activity and enzyme inhibitory potency. Nine out of eighteen derivatives (6–8, 10, 12–15, 18) are novel molecules synthesized for the first time in this work, and other derivatives were previously synthesized by our group. The compounds were characterized by Proton nuclear magnetic resonance, carbon nuclear magnetic resonance, fourier transform infrared spectroscopy, and elemental anal… Show more
“…Aggression, hallucinations, and delusions grow more frequently as illness worsens ( Lyketsos et al, 2011 ). AChE, an important biochemical enzyme from cholinesterase family, is recognized as primary pharmacological target for treating AD ( Arslan et al, 2020 ; Cavdar et al, 2019 ; Poslu et al, 2023 ). AChE regulates neuronal signal transmission by controlling ChE in CNS (central nervous system).…”
“…Aggression, hallucinations, and delusions grow more frequently as illness worsens ( Lyketsos et al, 2011 ). AChE, an important biochemical enzyme from cholinesterase family, is recognized as primary pharmacological target for treating AD ( Arslan et al, 2020 ; Cavdar et al, 2019 ; Poslu et al, 2023 ). AChE regulates neuronal signal transmission by controlling ChE in CNS (central nervous system).…”
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