Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson’s Disease Agents

Stefano, Antonio Di; Marinelli, Lisa; Eusepi, Piera; Ciulla, Michele; Fulle, Stefania; Filippo, Ester Sara Di; Magliulo, Laura; Biase, Giuseppe Di; Cacciatore, Ivana

doi:10.3390/biom9060239

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Indeed, the antioxidant activity of compound 6 was also evaluated using an H 2 DCFDA assay ( Figure 6). This assay is one of the most widely used techniques for directly measuring the redox state of a cell [56][57][58]. In order to accurately measure ROS and the cellular capability to counteract the H 2 O 2 insult, we used cell-permeable fluorescent and chemiluminescent probes.…”

Section: Biologymentioning

confidence: 99%

“…C2C12 cells were plated (2000 cells/well) into special optics 96-well plates (Corning-Costar, New York, NY, USA) and the cells were treated with RSV at 1 µM and Compound 6 at 1 and 10 µM for 24 h. After the incubation, cells were washed with an imaging buffer and treated with 300 µM H 2 O 2 for an immediate fluorescence measurement. Plates were read every 50 s from 0 to 10 min for kinetic data analysis using a microplate reader (Synergy H1, BioTek), with excitation and emission wavelengths at 490 nm and 520 nm, respectively, and analyzed by Gen 5 version 2.08 (BioTek) [56].…”

Section: Measurement Of Intracellular Rosmentioning

confidence: 99%

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Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

et al. 2020

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The increased risk of illness and disability is related to the age inevitable biological changes. Oxidative stress is a proposed mechanism for many age-related diseases. The crucial importance of polyphenol pharmacophore for aging process is largely described thanks to its effects on concentrations of reactive oxygen species. Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV) plays a critical role in slowing the aging process but has a poor bioavailabity after oral intake. In this present work, a series of RSV derivatives was designed, synthesized, and evaluated as potential antioxidant agents. These derivatives contain substituents with different electronic and steric properties in different positions of aromatic rings. This kind of substituents affects the activity and the bioavailability of these compounds compared with RSV used as reference compound. Studies of Log P values demonstrated that the introduction of halogens gives the optimum lipophilicity to be considered promising active agents. Among them, compound 6 showed the higher antioxidant activity than RSV. The presence of trifluoromethyl group together with a chlorine atom increased the antioxidant activity compared to RSV.

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Section: Biologymentioning

confidence: 99%

Section: Measurement Of Intracellular Rosmentioning

confidence: 99%

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

et al. 2020

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“…An oxidoreductase is involved in the synthesis of 3,4-dihydroxylphenyl alanine (DOPA), and 3,4-dihydroxylphenyl alanine is a drug used for treatment of Parkinson's disease [41]. Similarly, a class of oxidoreductase called monoamine oxidase (MAO) catalyzes enantiomeric desymmetrization of bicyclic proline intermediate, which is an important precursor in the synthesis of boceprevir.…”

Section: Oxidoreductase Enzymes In Pharmaceutical Industriesmentioning

confidence: 99%

Biological Application and Disease of Oxidoreductase Enzymes

Habte¹,

Beyene²

2021

Oxidoreductase

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In biochemistry, oxidoreductase is a large group of enzymes that are involved in redox reaction in living organisms and in the laboratory. Oxidoreductase enzymes catalyze reaction involving oxygen insertion, hydride transfer, proton extraction, and other essential steps. There are a number of metabolic pathways like glycolysis, Krebs cycle, electron transport chain and oxidative phosphorylation, drug transformation and detoxification in liver, photosynthesis in chloroplast of plants, etc. that require the direct involvements of oxidoreductase enzymes. In addition, degradation of old and unnecessary endogenous biomolecules is catalyzed by a family of oxidoreductase enzymes, e.g., xanthine oxidoreductase. Oxidoreductase enzymes use NAD, FAD, or NADP as a cofactor and their efficiency, specificity, good biodegradability, and being studied well make it fit well for industrial applications. In the near future, oxidoreductase may be utilized as the best biocatalyst in pharmaceutical, food processing, and other industries. Oxidoreductase play a significant role in the field of disease diagnosis, prognosis, and treatment. By analyzing the activities of enzymes and changes of certain substances in the body fluids, the number of disease conditions can be diagnosed. Disorders resulting from deficiency (quantitative and qualitative) and excess of oxidoreductase, which may contribute to the metabolic abnormalities and decreased normal performance of life, are becoming common.

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“…The -SH group is able to actively contrast ROS, conferring antioxidant properties to the molecule [55]. At the same time, NAC and its analogues contribute to the physiological antioxidant activity by acting as a GSH precursor [56,57].…”

Section: Natural Compounds Useful In the Prevention And Managementmentioning

confidence: 99%

Role of Dietary Supplements in the Management of Parkinson’s Disease

et al. 2019

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The use of food supplements or functional food has significantly increased in the past decades, especially to compensate both the modern lifestyle and the food shortages of the industrialized countries. Despite food supplements are habitually intended to correct nutritional deficiencies or to support specific physiological functions, they are often combined with common drug therapies to improve the patient’s health and/or mitigate the symptoms of many chronic diseases such as cardiovascular diseases, cystic fibrosis, cancer, liver and gastrointestinal diseases. In recent years, increased attentions are given to the patient’s diet, and the use of food supplements and functional food rich in vitamins and antioxidants plays a very important role in the treatment and prevention of neurodegenerative diseases such as Parkinson’s disease (PD). Natural compounds, phytochemicals, vitamins, and minerals can prevent, delay, or alleviate the clinical symptoms of PD in contrast to some of the main physiopathological mechanisms involved in the development of the disease, like oxidative stress, free radical formation, and neuroinflammation. The purpose of this review is to collect scientific evidences which support the use of specific biomolecules and biogenic elements commonly found in food supplements or functional food to improve the clinical framework of patients with PD.

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Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson’s Disease Agents

Cited by 9 publications

References 22 publications

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

Biological Application and Disease of Oxidoreductase Enzymes

Role of Dietary Supplements in the Management of Parkinson’s Disease

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