Synthesis and Biological Evaluation of Novel γ‐Alkylidene Butenolides

Liu, Gai-Zhi; Guan, Yanbin; Wu, Yangjie; Liu, Hong‐Min

doi:10.1155/2013/926723

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…An important structural motif, which is present in a number of pharmacologically active natural and synthetic compounds, is butenolide 176 . − This structural unity is also a building block for the construction of complex molecules, and their importance in synthetic organic and medicinal chemistry has motivated the development of a number of synthetic methodologies to prepare polysubstituted butenolides. − …”

Section: α-Keto Acids In Cyclization Reactionsmentioning

confidence: 99%

α-Keto Acids: Acylating Agents in Organic Synthesis

et al. 2019

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A significant number of important acyl-transfer reactions, such as direct acylation, ortho acylation, heteroatom acylation, and a diversity of cyclization reactions using the title compound as a key starting material, have been described in recent years. Just like a sleeping beauty, α-oxocarboxylic acids were awakened from a 17-year sleep to become important reagents in classical and new acylation reactions. The greener characteristic of the coproduct formed in reactions using α-keto acid (only CO 2 ), together with its versatility as a building block in catalytic organic synthesis, accredit it as a candidate to green acylating agent, an alternative to acyl chloride, and other acyl-transfer reagents. This review presents the impressive breakthroughs achieved mainly in the past decade in the development of new catalytic reactions for the formation of C−C, C−N, and C−S bonds using α-keto acids. CONTENTS 1. Introduction 7113 2. Classical Methods and Recent Advances in the Synthesis of α-Keto Acids 7115 2.1. Physical Properties of α-Keto Acids 7119 3. α-Keto Acids in Acylation Reactions 7119 3.1.

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Section: α-Keto Acids In Cyclization Reactionsmentioning

confidence: 99%

α-Keto Acids: Acylating Agents in Organic Synthesis

et al. 2019

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Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-Cancer Activity

El-Hameed

El-Shanbaky

Mohamed

2022

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Background: 2-Furanones attracted great attention due to their biological activities. They also have the ability to convert to several biologically active heterocyclic and non-heterocyclic compounds, especially as anti-cancer agents. Objectives: This research aims to assist in the development process of novel cytotoxic agents through synthesizing certain 2-furanone derivatives, using them as starting materials for the preparation of novel heterocyclic and non-heterocyclic compounds, and then testing the synthesized derivatives for their anti-cancer activities. Methods: All the newly synthesized compounds were fully characterized by elemental analysis, IR, Mass, and 1H-NMR spectroscopy. 18 synthesized compounds were selected by National Cancer Institute (NCI) for testing against 60 cell lines, and the active compound was tested as MAPK14 and VEGFR2-inhibitor using Staurosporine as standard. Results: Compound 3a showed higher activity against several cell lines, including leukemia (SR), Non-Small Cell Lung Cancer (NCI-H460), colon cancer (HCT-116), ovarian cancer (OVCAR-4), renal cancer (786-0, ACHN and UO-31), and finally breast cancer (T-47D). It also had better inhibition activity against MAPK14 than the used reference. Conclusion: Compound 3a has promising anti-cancer activities compared to the used standards and may need further modifications and investigations.

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Synthesis and Biological Evaluation of Novel γ‐Alkylidene Butenolides

Cited by 2 publications

References 41 publications

α-Keto Acids: Acylating Agents in Organic Synthesis

α-Keto Acids: Acylating Agents in Organic Synthesis

Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-Cancer Activity

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