Synthesis and biological evaluation of sulfonamide thiazole and benzothiazole derivatives as antimicrobial agents

Argyropoulou, Iro; Geronikaki, Athina; Vicini, Paola; Zani, Franca

doi:10.3998/ark.5550190.0010.611

Cited by 92 publications

(31 citation statements)

References 19 publications

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“…In the 1 H NMR spectrum of this compound, the methylene proton signals of the thiazolone ring were observed as a singlet at 3.93 ppm and the corresponding 13 C signal at 40.58. Bromination of compound 2, performed in acetic acid at room temperature, gave the expected product, 3-[(5,5-dibromo-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(4-fluorophenyl)amino]propanoic acid (3). The methylene group in the five-membered heterocyclic ring easily participates in condensation reactions with carbaldehydes.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and antibacterial, antifungal activity of N-(4-fluorophenyl)-N-carboxyethylaminothiazole derivatives

Vaickelionienė¹,

Mickevičius²,

Vaickelionis³

et al. 2015

Arkivoc

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A series of novel N-(4-fluorophenyl)-N-carboxyethylaminothiazoles and thiazolones with aliphatic, aromatic and heterocyclic substituents were obtained in good to excellent overall yields. The synthesized compounds were screened for their antimicrobial and antifungal activity. The antibacterial tests indicated that the functionalized aminothiazole derivatives exhibit a higher activity as compared with thiazolone derivatives.

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Section: Resultsmentioning

confidence: 99%

Synthesis and antibacterial, antifungal activity of N-(4-fluorophenyl)-N-carboxyethylaminothiazole derivatives

Vaickelionienė¹,

Mickevičius²,

Vaickelionis³

et al. 2015

Arkivoc

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“…However, the specific effects of the CECs varied, among the organisms. CECs have been observed to exhibit growth promoting effects on microbes (Carvalho et al, 2010;Zimmermann and Curtis, 2017), while growth inhibition by these chemicals typically occurs at higher concentrations (Koch and Burchall, 1971;Kabbash et al, 2004;Argyropoulou et al, 2009;Al-Janabi, 2010). For these reasons we predicted that the microorganisms would not be affected the presence of CECs.…”

Section: Impact Of Cecs On Microorganism Growthmentioning

confidence: 94%

Chemicals of Emerging Concern in Treated Wastewater Impact Microbial Growth

McLain

Gachomo

2019

Front. Environ. Sci.

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Agriculture production in California is negatively impacted by soilborne fungi, such as Verticillium dahliae, and limited water availability for irrigation. Some regions have adapted the use of recycling wastewater, i.e., reclaimed water, to supplement the potable water supply. Wastewater purification is not fully efficient at removing all contaminants and small amounts of pharmaceutical products, known as chemicals of emerging concern (CECs), remain. Acetaminophen, trimethoprim, sulfamethoxazole and gemfibrozil are some of the most common CECs found in treated wastewater and were therefore used in this study. These CECs were evaluated for their potential to interact with microorganisms directly, or for their ability to alter the development of Verticillium wilt disease in eggplants. The microorganisms Verticillium dahliae, Fusarium oxysporum f. sp. lycopersici, Piriformospora indica, Phytopthora capsici, and Bradyrhizobium japonicum were used for in vitro growth assays in the presence of CECs. CECs induced varying responses in strains of the same fungi by promoting growth of one strain while inhibiting growth of the other. CECs influenced spore germination of V. dahliae and F. oxysporum. Greenhouse experiments in which Solanum melongena (eggplants) were inoculated with V. dahliae and irrigated with CECs were used to evaluate the impacts of these chemicals on disease development. Overall our results found that most of the organisms we tested were sensitive to the CECs. P. capsici was found to be the most sensitive microorganism, while B. japonicum growth was unaffected by the CECs at the concentrations used. The greenhouse assays results indicated that plant disease severity may be influenced by given CECs at certain stages of plant growth. Overall the results of this study indicate that the concentrations of CECs found in reclaimed water are occurring at biologically relevant concentrations.

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“…The benzothiazole derivatives show wide range of biological activities which include analgesic 1 , anti-inflammatory 2 , antiviral 3 , antibacterial 4 and anticancer activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Screening of Biologically Active Schiff bases of Benzothiazoles and its Zinc and Lanthanum Metal Complexes

et al. 2021

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The substituted 2-Aminobenzothiazole and ethyl 2-(4-formyl-3-hydroxyphenyl)-4-methylthiazole-5-carboxylate in methanol mix together and heat the reaction mixture for overnight, It gives Schiff’s bases (derivatives of substituted aminobenzothiazole) 3. This compound 3 when treated with Zinc Chloride it gives Zinc metal complex of Schiff’s bases 4 and if compound 3 was treated with Lanthanum chloride gives Lanthanum metal complex of Schiff’s bases 5, which shows marked biological activities.

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Synthesis and biological evaluation of sulfonamide thiazole and benzothiazole derivatives as antimicrobial agents

Cited by 92 publications

References 19 publications

Synthesis and antibacterial, antifungal activity of N-(4-fluorophenyl)-N-carboxyethylaminothiazole derivatives

Synthesis and antibacterial, antifungal activity of N-(4-fluorophenyl)-N-carboxyethylaminothiazole derivatives

Chemicals of Emerging Concern in Treated Wastewater Impact Microbial Growth

Synthesis and Screening of Biologically Active Schiff bases of Benzothiazoles and its Zinc and Lanthanum Metal Complexes

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