Synthesis and Biological Evaluation of Phthalideisoquinoline Derivatives

Abstract

A photo and Cu-mediated radical−radical approach enabling the one-step synthesis of the phthalideisoquinoline skeleton has been reported. Under mild reaction conditions, a series of N-aryl phthalideisoquinolines containing various substituents were synthesized in moderate to good yields. Bioactivity data demonstrated that a new compound 4x can efficiently inhibit the growth of multiple tumor cell lines with enhancements of more than 10-fold by significantly increasing G 2 /M arrest compared with noscapine.